DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and RAX

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_038463.2	Gene:	RAX / 30062	HGNCID:	18662	Length:	346	Species:	Homo sapiens

Alignment Length:	310	Identity:	96/310 - (30%)
Similarity:	123/310 - (39%)	Gaps:	128/310 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 GEGENSNG-------GASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFA 500
            ||...|.|       |.:.:  :|::|.    |:|.:||||:||..|:..||:.||::|||||::
Human   107 GEARPSPGLPVGPATGEAKL--SEEEQP----KKKHRRNRTTFTTYQLHELERAFEKSHYPDVYS 165

  Fly   501 RERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLS 565
            ||.||||:.|||.|:||||.||||||||:|||.                  .::..|.|||
Human   166 REELAGKVNLPEVRVQVWFQNRRAKWRRQEKLE------------------VSSMKLQDSP---- 208

  Fly   566 ACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPT----PIPH-IRPSCTSDN 625
                |||.|...||          :|||      .||||..|...|.    |:.. :.|
Human   209 ----LLSFSRSPPS----------ATLS------PLGAGPGSGGGPAGGALPLESWLGP------ 247

  Fly   626 DNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHT 690
                            ||..||   ...:||         :|...|                  .
Human   248 ----------------PLPGGG---ATALQS---------LPGFGP------------------P 266

  Fly   691 ALSMSDSYGAVTPIPSFNHS-----AVGPLAPPSPIPQQGDLTPSSLYPC 735
            |.|:..||....|.|.|.:|     .:.|||||.|           .|||
Human   267 AQSLPASYTPPPPPPPFLNSPPLGPGLQPLAPPPP-----------SYPC 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	33/51 (65%)
RAX	NP_038463.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..145		14/43 (33%)
		Homeobox	140..192	CDD:278475	33/51 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..318		49/217 (23%)
		OAR	319..335	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910