DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Hoxd3

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001257967.1	Gene:	Hoxd3 / 288152	RGDID:	1588601	Length:	432	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	118/516 - (22%)
Similarity:	178/516 - (34%)	Gaps:	151/516 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 SSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPN 333
            |.:||....:||........|:||               |::.:.:....::  .:|||  ::|.
  Rat    35 SKATDAYGYSTPHQPYPPPAAANS---------------LDSDYPSSACSIQ--SSAPL--RAPA 80

  Fly   334 HLGTR---------SSHPQLVHGNHQ--ALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIAS 387
            |.|..         :.:.|...|.:|  .|...||...||..     .||    :|.||..|
  Rat    81 HKGAELNGSCMRPGTGNSQGGGGGNQPPGLNSEQQPPQPPPP-----PPT----LPPSSPTN--- 133

  Fly   388 VTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIH--LKKELDGHQSDETGSGEGENSN- 449
               ..||.....:...||...|.::|..|         |.  :|:.....:...:.:..|||..
  Rat   134 ---PGSGVPAKKTKGGPNASSSSSTISKQ---------IFPWMKESRQNSKQKNSCATSGENCED 186

  Fly   450 ----GGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGL 510
                |.||                  :|.||::|:.|:..|||||....|.....|..:|..:.|
  Rat   187 KSPPGPAS------------------KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNL 233

  Fly   511 PEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSA 575
            .|.:|::||.|||.|:::::|.:....:|..                 .||..    |..|.|:|
  Rat   234 TERQIKIWFQNRRMKYKKDQKAKGILHSPAG-----------------QSPER----SPPLGGAA 277

  Fly   576 GGPSVS----TINGL-----SSPSTLSTNVNAPTLGAGIDSSESPTP------IPHIRPSCTSDN 625
            |..:.|    .:.||     |.|:...:..|...|.|......|..|      .|...|...:.|
  Rat   278 GHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASN 342

  Fly   626 DNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHT 690
            ..|..|.:.:    ..|:.|||    :.:.|        :.||..|  .||.|       ::.|.
  Rat   343 GGGFASANLQ----GSPVYVGG----NFVDS--------MAPASGP--VFNLG-------HLSHP 382

  Fly   691 ALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHI 751
            : |.|..|.....||..:|.     .|..|.|...||:..     |.:....|.||...|:
  Rat   383 S-SASVDYSCAAQIPGNHHH-----GPCDPHPTYTDLSAH-----HTSQGRLPEAPKLTHL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	21/51 (41%)
Hoxd3	NP_001257967.1	Homeobox	198..251	CDD:395001	21/52 (40%)
Hoxd3	NP_001257967.1	DUF4074	369..430	CDD:404218	21/80 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910