DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and PDLIM3

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_055291.2	Gene:	PDLIM3 / 27295	HGNCID:	20767	Length:	364	Species:	Homo sapiens

Alignment Length:	347	Identity:	67/347 - (19%)
Similarity:	101/347 - (29%)	Gaps:	97/347 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 PSTLSTNVNAP---TLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCP-------L 643
            |.|:.....||   .|..|||.:: |..|..|.|...:            ...:.||       .
Human     2 PQTVILPGPAPWGFRLSGGIDFNQ-PLVITRITPGSKA------------AAANLCPGDVILAID 53

  Fly   644 GVGGHQNTH-HIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSF 707
            |.|....|| ..|....|..|.|.      |..:.|       ..|..:..:|:. |...|....
Human    54 GFGTESMTHADAQDRIKAAAHQLC------LKIDRG-------ETHLWSPQVSED-GKAHPFKIN 104

  Fly   708 NHSAVGPLAPPSPIPQQGDLTPSSLYPCHM-TLRPPPMAPAHHHIVPGDG---GRPAGVGLGSGQ 768
            ..|.          ||.|:      |..|. .:||.|.      ::||..   ..|:|:..|||:
Human   105 LESE----------PQDGN------YFEHKHNIRPKPF------VIPGRSSGCSTPSGIDCGSGR 147

  Fly   769 S-----ANLGASCSGS------------------GYEVLSAYALPPPPMASSSAADSSFSAASSA 810
            |     :.:...|.|.                  |.:::.|....|..:.|......:.....|.
Human   148 STPSSVSTVSTICPGDLKVAAKLAPNIPLEMELPGVKIVHAQFNTPMQLYSDDNIMETLQGQVST 212

  Fly   811 SANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSS-- 873
            :...||   :..|...|....:..:.:.|.:  .::|..|..|....:........:...|:.
Human   213 ALGETP---LMSEPTASVPPESDVYRMLHDN--RNEPTQPRQSGSFRVLQGMVDDGSDDRPAGTR 272

  Fly   874 ---ASGTSAHVAPGKQQFFASC 892
               |..|..|...|..|....|
Human   273 SVRAPVTKVHGGSGGAQRMPLC 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475
PDLIM3	NP_055291.2	PDZ_signaling	2..80	CDD:238492	23/96 (24%)
		DUF4749	184..263	CDD:374237	12/83 (14%)
		LIM_ALP	294..346	CDD:188834	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030