DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and VENTX

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_055283.1	Gene:	VENTX / 27287	HGNCID:	13639	Length:	258	Species:	Homo sapiens

Alignment Length:	252	Identity:	66/252 - (26%)
Similarity:	102/252 - (40%)	Gaps:	40/252 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 SLSPPNDIESLASIG-----HQRNCPVATEDIHLKKELDGHQSDETGSGEGENSN---------- 449
            |.|||...:.|:|.|     .|.:|...|   |..:..|.......|.|:...:.
Human     4 SSSPPRGPQQLSSFGSVDWLSQSSCSGPT---HTPRPADFSLGSLPGPGQTSGAREPPQAVSIKE 65

  Fly   450 -GGASNIGNTEDDQARLILK---RKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGL 510
             .|:||:...|...|.|..:   .:..|.||:||.:|:.:||..|:...|.....|:|||.::.|
Human    66 AAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQL 130

  Fly   511 PEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTD--------SPNSLSAC 567
            .|.:|:.||.|||.|.:|:.: ..|..:|.|....|..:..|.::.|.:        :|.|....
Human   131 SEVQIKTWFQNRRMKHKRQMQ-DPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQA 194

  Fly   568 SSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTP-IPHIRPSCTS 623
            ..|..||..|........|:|       ..|...|..: :|..||| .|.:.|:.::
Human   195 LMLPPGSFWGLCQVAQEALAS-------AGASCCGQPL-ASHPPTPGRPSLGPALST 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	22/51 (43%)
VENTX	NP_055283.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		20/91 (22%)
		Homeobox	95..147	CDD:306543	22/51 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..248		6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910