DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Mixl1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_038757.1	Gene:	Mixl1 / 27217	MGIID:	1351322	Length:	231	Species:	Mus musculus

Alignment Length:	229	Identity:	64/229 - (27%)
Similarity:	95/229 - (41%)	Gaps:	46/229 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 GPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSG---EGENSNGGASNI 455
            |..|..::.|.:   .|.:..|....|.||:..   ...|...:.:|.:|   .|.:....|.:.
Mouse    26 GGQLLPAMRPAS---GLPAAPHDSRAPAATQCF---PNRDSSPTAQTPAGLDPPGPSKGSAAPSA 84

  Fly   456 GNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFS 520
            ..              :|.||||:::|:..||..|.:|.|||:..|||||....|||:||||||.
Mouse    85 PQ--------------RRKRTSFSSEQLQLLELVFRQTMYPDIHLRERLAALTLLPESRIQVWFQ 135

  Fly   521 NRRAKWRRE-----EKLRNQRRT-----PNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSA 575
            |||||.||:     :.|.::|..     ...|.|..........|.:...|:.        |.:.
Mouse   136 NRRAKSRRQSGKSFQPLSSRRGVFLHCPAPGTEARCLKPQLPLEADVNHVPDP--------SMTG 192

  Fly   576 GGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSE 609
            ||...|......:.|:||.::     |:.:||.|
Mouse   193 GGVCTSGSQSFETYSSLSEDI-----GSKLDSWE 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	31/51 (61%)
Mixl1	NP_038757.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..93		16/86 (19%)
Mixl1	NP_038757.1	Homeobox	89..142	CDD:278475	31/52 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810