DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and GBX2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001476.2	Gene:	GBX2 / 2637	HGNCID:	4186	Length:	348	Species:	Homo sapiens

Alignment Length:	272	Identity:	68/272 - (25%)
Similarity:	107/272 - (39%)	Gaps:	55/272 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 MQTATP-------LNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSP 332
            :|.|.|       :.|..:|..|:..:|         :.|.:|..|..||..         ..||
Human    70 LQPALPPAHPHHQIPSLPTGFCSSLAQG---------MALTSTLMATLPGGF---------SASP 116

  Fly   333 NH---LGTRSSHPQLVHG-----NHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVT 389
            .|   ...|...||.:.|     ..:|||...:.........||....|.:|...:|.  :.:|.
Human   117 QHQEAAAARKFAPQPLPGGGNFDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQASL--VGAVR 179

  Fly   390 AYASGPSLAHSLSPPNDIESL---ASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGG 451
            ......|.... .|....||.   :.:.:..:..:..:..| |:|..||..:||....|  :.|.
Human   180 GQGKDESKVED-DPKGKEESFSLESDVDYSSDDNLTGQAAH-KEEDPGHALEETPPSSG--AAGS 240

  Fly   452 ASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQ 516
            .::.|             |.:|.||:||::|:..|||||....|..:..|.::|..:.|.|.:::
Human   241 TTSTG-------------KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVK 292

  Fly   517 VWFSNRRAKWRR 528
            :||.||||||:|
Human   293 IWFQNRRAKWKR 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	22/51 (43%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..81		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..139		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..251		16/88 (18%)
		Homeobox	250..303	CDD:306543	22/52 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910