DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and phx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_593776.1	Gene:	phx1 / 2542405	PomBaseID:	SPAC32A11.03c	Length:	942	Species:	Schizosaccharomyces pombe

Alignment Length:	516	Identity:	119/516 - (23%)
Similarity:	192/516 - (37%)	Gaps:	147/516 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 NSSESGGASNSGEGSEQE---AIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQ 343
            ::.|:||..|......::   .:.|.|.|.|....:            .:||.|:     .::.|
pombe     5 SNPENGGQINDNINYSEKRPTMLPENLSLSNYDMDS------------FLGQFPS-----DNNMQ 52

  Fly   344 LVHGNH-QALQQHQQQSWPPRHYSGSWYPTSL---SEIPISSAPNIASVTAYAS-GPSLAHSLSP 403
            |.|..: |.||..||....|.::...:....:   .|.|...||:.|...::.: ..|...:.||
pombe    53 LPHSTYEQHLQGEQQNPTNPNYFPPEFDENKVDWKQEKPKPDAPSFADNNSFDNVNSSKLTNPSP 117

  Fly   404 --PNDIESLAS-IGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARL 465
              ||.::|.:. ...::|..|....:...||...|:|       |...:||:::..
pombe   118 VQPNIVKSESEPANSKQNEVVEATSVEKAKENVAHES-------GTPESGGSTSAP--------- 166

  Fly   466 ILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAK----W 526
              |.|.||    .|.||:..|.:||.:...|....||::..::.:||..:.:||.|||||    .
pombe   167 --KSKKQR----LTADQLAYLLREFSKDTNPPPAIREKIGRELNIPERSVTIWFQNRRAKSKLIS 225

  Fly   527 RREEK-----LRNQRRTPNSTGASATSSSTSATASLTDSPN---SLSACSSLLSGSAGGPSVSTI 583
            ||:|:     ||.||.                    .||.|   |.:....:||.|...|.|..|
pombe   226 RRQEEERQRILREQRE--------------------LDSLNQKVSQAFAHEVLSTSPTSPYVGGI 270

  Fly   584 NGLSSPSTLSTNVNAPTLGAG--------IDSSESPTPIPHIRPSCTSDNDNG-RQSEDCRRVCS 639
              .::....:|.:..||...|        :.||..|         |.:::|.. |||
pombe   271 --AANRQYANTLLPKPTRKTGNFYMKSGPMQSSMEP---------CIAESDIPIRQS-------- 316

  Fly   640 PCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPI 704
                    ..:|::...:.:|     ||..|.| .:::.|:.|:     ..|:|:|:....|...
pombe   317 --------LSSTYYNSLSPNA-----VPVSSQR-KYSASSYSAI-----PNAMSVSNQAFDVESP 362

  Fly   705 PSFNHSAVGPLAPPSP------IPQQ-----------GDLTPSSLYPCHMTLRPPPMAPAH 748
            ||...:.:..:..|.|      .|::           |...||| |.....:|||.||..|
pombe   363 PSSYATPLTGIRMPQPESDLYSYPREVSPSSGGYRMFGHSKPSS-YKASGPVRPPNMATGH 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	18/55 (33%)
phx1	NP_593776.1	COG5576	116..272	CDD:227863	53/199 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840