DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Alx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_037053.1	Gene:	Alx1 / 25401	RGDID:	2273	Length:	326	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	90/320 - (28%)
Similarity:	125/320 - (39%)	Gaps:	65/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 VTAYASGPSLAHSL-----SPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGEN 447
            |.|:...|...|.:     ||..|......|......|:.||   |.:.:||..:......:|..
  Rat    50 VQAFGPLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTE---LNRAMDGCNNLRMSPVKGMP 111

  Fly   448 SNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPE 512
            .......:|:..|..   :...|.:|:||:||:.|::.|||.|::||||||:.||:||.:..|.|
  Rat   112 EKSELDELGDKCDSN---VSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTE 173

  Fly   513 ARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGG 577
            ||:||||.|||||||:.|:....::..:...|:...|....|.|.....|:|.|      |:..|
  Rat   174 ARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWA------GNTSG 232

  Fly   578 PSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCP 642
            .||.|...|..                 |:|...||..|   |..:|:..
  Rat   233 GSVVTSCMLPR-----------------DASSCMTPYSH---SPRTDSSY--------------- 262

  Fly   643 LGVGGHQNTH-HIQSN---------GHAQGHALVPAISPRLNFNSGSFGAM-YSNMHHTA 691
            .|...|||.. |:..|         |...|||.  ...|.....|.|...: .....|||
  Rat   263 TGFSNHQNQFGHVPLNNFFTDSLLTGTTNGHAF--ETKPEFERRSSSIAVLRMKAKEHTA 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
Alx1	NP_037053.1	Homeobox	135..188	CDD:278475	32/52 (62%)
		Transactivation domain. /evidence=ECO:0000269\|PubMed:12390248	192..326		36/172 (21%)
		OAR	302..319	CDD:281777	2/16 (13%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319		1/12 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910