DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Ldb3

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_036048.3	Gene:	Ldb3 / 24131	MGIID:	1344412	Length:	723	Species:	Mus musculus

Alignment Length:	431	Identity:	93/431 - (21%)
Similarity:	150/431 - (34%)	Gaps:	143/431 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   560 SPNSLSACSSLLSG----SAGGPSVSTINGLSSPSTL-STNVNAPTLGAGIDSSESPTPIPHIRP 619
            :|.|.:|.|.|..|    :..|.:..|:..|.:.:.: |.:.|   |...:..|:.|.||....|
Mouse    33 TPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYN---LSLTLQKSKRPIPISTTAP 94

  Fly   620 SCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGS--FGA 682
            ...|                  ||.|..||....:.:|    |....|:.||....:.|:  ||.
Mouse    95 PIQS------------------PLPVIPHQKDPALDTN----GSLATPSPSPEARASPGALEFGD 137

  Fly   683 MY-SNMHHTAL--SMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPM 744
            .: |:...|::  .:.::.|.|.|:.|       |:|..|....||.::|..|        |.|.
Mouse   138 TFSSSFSQTSVCSPLMEASGPVLPLGS-------PVAKASSEGAQGSVSPKVL--------PGPS 187

  Fly   745 APAHHHIVPG-----------------DGGRPAGVGLGSG------------------------- 767
            .|..::...|                 ..|:.:|.||..|
Mouse   188 QPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGAGLLGGSLPVKDLAVDSASPVYQAVIKTQSK 252

  Fly   768 ----------QSANLG-------ASCSGSGY------EVL--SAYALPPPPMASSSAADSSFSAA 807
                      :|:||.       |..:|:.|      |.|  |:..:...|:.:|.|......|:
Mouse   253 PEDEADEWARRSSNLQSRSFRILAQMTGTEYMQDPDEEALRRSSTPIEHAPVCTSQATSPLLPAS 317

  Fly   808 SSASANVTPHHTIAQESCPSP---CSSASHFGVAHSSGFSSDPIS---PAVSSY----------- 855
            :.:.|..:|   ||    .||   .::|:|...|.::|.::.|:.   |..|:|
Mouse   318 AQSPAAASP---IA----ASPTLATAAATHAAAASAAGPAASPVENPRPQASAYSPAAAASPAPS 375

  Fly   856 AHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSP 896
            ||.||:...:|....|...  |:|.:.|...|...:..|||
Mouse   376 AHTSYSEGPAAPAPKPRVV--TTASIRPSVYQPVPASSYSP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475
Ldb3	NP_036048.3	PDZ_signaling	5..81	CDD:238492	12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..134		14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..193		11/43 (26%)
		DUF4749	191..293	CDD:374237	13/101 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..423		36/144 (25%)
		PHA03247	<378..528	CDD:223021	11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..525
		LIM1_ZASP_Cypher	547..598	CDD:188838
		LIM2_Enigma_like	606..657	CDD:188748
		LIM3_ZASP_Cypher	665..719	CDD:188844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030