DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and Pou2f3

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_035269.2	Gene:	Pou2f3 / 18988	MGIID:	102565	Length:	431	Species:	Mus musculus

Alignment Length:	447	Identity:	100/447 - (22%)
Similarity:	150/447 - (33%)	Gaps:	145/447 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 GTLSSSTDLMQTATPLNSSESGGASNSGEGSEQ---EAIYEKLRLLNTQHAAGPGPLEPARAAPL 327
            |.::.|||   |.:.....|.|...|..:.:.|   |.:.:.|:                   ..
Mouse    15 GDVADSTD---TRSTFGQVEPGNDRNGLDFNRQIKTEDLGDSLQ-------------------QT 57

  Fly   328 VGQSPNHLGTRSSHPQLVHGNHQ-----ALQQHQQQSWPPRHYSGSWYPTSLSEIPISSA----- 382
            :...|.||   |..|.::.||..     :|...||....|.|..      |:|:..:|..
Mouse    58 LSHRPCHL---SQGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQ------SVSQFLLSQTPPGQQ 113

  Fly   383 ---PNIASVTAYAS-------GPSLA-----------HSLSP----------------------P 404
               ||:.|.....|       ||.||           .||.|                      |
Mouse   114 GLQPNLLSFPQQQSTLLLPQTGPGLASQAVGRPGLSGSSLEPHLDAPQHLPGPKHLPGPGGNDEP 178

  Fly   405 NDIESL---ASIGHQRNCPVA-TE-DIHLKK-ELDGHQSDETGSGEGENSNGGASNI-------- 455
            .|:|.|   |....||...:. |: |:.|.. :|.|:...:|.....|..|....|:
Mouse   179 TDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLE 243

  Fly   456 -------GNTEDDQARL---------ILKRKLQRNRTSF-TNDQIDSLEKEFERTHYPDVFARER 503
                   .:..|..|..         :..|| ::.|||. ||.:: :|||.|:....|.......
Mouse   244 KWLNDAESSPSDPSASTPSSYPTLSEVFGRK-RKKRTSIETNIRL-TLEKRFQDNPKPSSEEISM 306

  Fly   504 LAGKIGLPEARIQVWFSNRRAKWRR---------EEKLRNQRRTPNSTGASATS-----SSTSAT 554
            :|.::.:.:..::|||.|||.|.:|         :..:.|.|....|......|     |:...|
Mouse   307 IAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPVKPPIYNSRLVSPSGSLGPLSVPPVHSTMPGT 371

  Fly   555 ASLTDSPNSLSACSSLLSG-SAGGPSVSTIN---GLSSPSTLSTNV-------NAPT 600
            .:.:.||.:.|..||..|| .|..|:.|..|   .::|.|:.|.|.       |.||
Mouse   372 VTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAMNSSSSSSFNSSGSWYRWNHPT 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	18/52 (35%)
Pou2f3	NP_035269.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..180		8/49 (16%)
		POU	176..250	CDD:197673	16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..275		4/28 (14%)
		Homeobox	277..330	CDD:278475	18/53 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..419		19/66 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910