DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and Pou2f1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_035267.2	Gene:	Pou2f1 / 18986	MGIID:	101898	Length:	793	Species:	Mus musculus

Alignment Length:	839	Identity:	187/839 - (22%)
Similarity:	285/839 - (33%)	Gaps:	255/839 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 KEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNV-ASGSRGTLS----SSTDLMQTATPLN---- 282
            |....:...|:.|........|..|.:||.:|.. |....|.|.    :.|.|...|..||
Mouse    32 KSSMESEDASTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSK 96

  Fly   283 -SSESGGASNSGEGSE-----QEAIYEKLRLL--------------------------------- 308
             |.|||.:..|.:.|.     |.||.:...:|
Mouse    97 SSEESGDSQQSSQPSSQPPSVQSAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAV 161

  Fly   309 -----NTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQ---------- 358
                 :.||:|....:..:.|.|:. |.|      .|.|..:..:.|.|||.|||
Mouse   162 QQHSASQQHSAAGATISASAATPMT-QIP------LSQPIQIAQDLQQLQQLQQQNLNLQQFVLV 219

  Fly   359 ----SWPPRHYSGSWYPTS----------LSEIPISSAPNI----ASVT------------AYAS 393
                :..|..:..|..|..          |:::|..|..|:    .|:|            |.||
Mouse   220 HPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQPQPSITLTSQPTTPTRTIAAAS 284

  Fly   394 GPSLAH-----------SLSPPNDIESL---ASIGHQRNCPVA-TE-DIHLKK-ELDGHQSDETG 441
            ..:|..           ||..|:|:|.|   |....||...:. |: |:.|.. :|.|:...:|.
Mouse   285 VQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT 349

  Fly   442 SGEGENSN-----------------GGASNIGNTEDDQARLILK---------RKLQRNRTSF-T 479
            ....|..|                 ..|.|:.:.....:...|.         .:.::.|||. |
Mouse   350 ISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSTASSPSALNSPGLGAEGLNRRRKKRTSIET 414

  Fly   480 NDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGA 544
            |.:: :|||.|.....|.......:|.::.:.:..|:|||.|||.|        .:|..|.|:|
Mouse   415 NIRV-ALEKSFMENQKPTSEDITLIAEQLNMEKEVIRVWFCNRRQK--------EKRINPPSSG- 469

  Fly   545 SATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSE 609
               .:|:|...::..||.||.|.:         ||:.|   .|:.:||:.|...|...|.:.:.
Mouse   470 ---GTSSSPIKAIFPSPASLVATT---------PSLVT---SSTATTLTVNPVLPLTSAAVTNL- 518

  Fly   610 SPTPIPHIRPSCTSDNDNGRQSEDCRRVCS-----PCPLGVGGHQNTHHIQSNGH---------- 659
                      |.|        .:|.||.||     ..|..|.....|....||.:
Mouse   519 ----------SLT--------DQDLRRGCSWEVLRSLPDRVTTTAGTTDSTSNNNTATVISTAPP 565

  Fly   660 AQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQ 724
            |......|::||..:.::.:..|..::..:|..:.|      ||:||       ||.     ..|
Mouse   566 ASSAVTSPSLSPSPSASASTSEASSASETNTTQTTS------TPLPS-------PLG-----ASQ 612

  Fly   725 GDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLS---- 785
            ..:|...|......|:.....||:..:    ....|..||..|..|   .|...:|..:||
Mouse   613 VMVTTPGLQTAAAALQGAAQLPANASL----AAMAAAAGLSPGLMA---PSQFAAGGALLSLSPG 670

  Fly   786 --AYALPPPPMASSSAADSSFSAASSA----SANVTPHHTIAQE-SCPSPCSSASHFGVAHSSGF 843
              ..||.|..|::|:.|.....|:|.:    |.:.|.:...|.. ..|:..::.......:.|..
Mouse   671 TLGSALSPALMSNSTLATIQALASSGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLL 735

  Fly   844 SSDPISPAVSSYAHMSYN-------YASSANT-------MTPSSASG-TSAHVAPGKQQ 887
            :|:|:| .||:.|..:.|       :|||.:|       .|.:|||| .|...|..|.|
Mouse   736 TSNPVS-LVSAAAASTGNSAPTASLHASSTSTESIQSSLFTVASASGPASTTTAASKAQ 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	19/52 (37%)
Pou2f1	NP_035267.2	POU	304..378	CDD:197673	15/73 (21%)
Pou2f1	NP_035267.2	Homeobox	408..461	CDD:278475	19/61 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910