DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Pitx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_035227.1	Gene:	Pitx1 / 18740	MGIID:	107374	Length:	315	Species:	Mus musculus

Alignment Length:	288	Identity:	84/288 - (29%)
Similarity:	126/288 - (43%)	Gaps:	67/288 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 SLSEIPISSAPNIASVTAYASGPS--LAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGH 435
            ||..:|....|  .....:..|||  ||.:..|...:|:.||.....:.|
Mouse     9 SLERLPEGLRP--PPPPPHDMGPSFHLARAADPREPLENSASESSDADLP--------------- 56

  Fly   436 QSDETGSGEG-ENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVF 499
            ..:..|..:| |:...|::..|...:|.|:   |:|.:|.||.||:.|:..||..|:|..|||:.
Mouse    57 DKERGGEAKGPEDGGAGSAGCGGGAEDPAK---KKKQRRQRTHFTSQQLQELEATFQRNRYPDMS 118

  Fly   500 ARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQR-------RTPNSTG---------ASATS 548
            .||.:|....|.|.|::|||.|||||||:.|  |||:       ..|..:|         |:..|
Mouse   119 MREEIAVWTNLTEPRVRVWFKNRRAKWRKRE--RNQQLDLCKGGYVPQFSGLVQPYEDVYAAGYS 181

  Fly   549 SSTSATASLTDSP---------NSLSACSSLLSGSAGGPSVSTINGLSSPSTLS----------- 593
            .:..|..||..:|         ||:|..||....||    .|:|:.::.||::.
Mouse   182 YNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSA----PSSISSMTMPSSMGPGAVPGMPNSG 242

  Fly   594 -TNVNAPTLGAGIDSSESPTPIPHIRPS 620
             .|:|..| |:.::|:.||...|:..|:
Mouse   243 LNNINNLT-GSSLNSAMSPGACPYGTPA 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	26/51 (51%)
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		29/114 (25%)
		Homeobox	94..147	CDD:365835	27/52 (52%)
		Interaction with PIT-1	151..280		30/124 (24%)
		Forkhead_N	196..>275	CDD:369872	20/79 (25%)
		OAR	277..294	CDD:367680
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	281..294
		Nuclear localization signal. /evidence=ECO:0000255	287..291
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940