DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Pdx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_032840.1	Gene:	Pdx1 / 18609	MGIID:	102851	Length:	284	Species:	Mus musculus

Alignment Length:	344	Identity:	81/344 - (23%)
Similarity:	122/344 - (35%)	Gaps:	85/344 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 SEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSW 360
            :.:|..|...:|.....|...||:....|.|   .:..::|.:...|.
Mouse     2 NSEEQYYAATQLYKDPCAFQRGPVPEFSANP---PACLYMGRQPPPPP----------------- 46

  Fly   361 PPRHYSGSWYPTSLSEIPISSAPNIA--SVTAYAS----GPSLAHSL--------SPPNDIESLA 411
            ||:      :.:||..:...|.|:|:  .|...||    |..|.|.|        .||...
Mouse    47 PPQ------FTSSLGSLEQGSPPDISPYEVPPLASDDPAGAHLHHHLPAQLGLAHPPPGPF---- 101

  Fly   412 SIGHQRNCPVATEDIHLKK------ELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRK 470
                    |..||...|::      .....:|.:..:.:|:.: |||......|:
Mouse   102 --------PNGTEPGGLEEPNRVQLPFPWMKSTKAHAWKGQWA-GGAYTAEPEEN---------- 147

  Fly   471 LQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQ 535
             :|.||::|..|:..|||||....|.....|..||..:.|.|..|::||.|||.||::||..:..
Mouse   148 -KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRS 211

  Fly   536 RRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPT 600
            ..||:..|.........|   :|.....|:.......|.|..|.|        |:.    |....
Mouse   212 SGTPSGGGGGEEPEQDCA---VTSGEELLAVPPLPPPGGAVPPGV--------PAA----VREGL 261

  Fly   601 LGAGIDSSESPTPIPHIRP 619
            |.:|:..|..|:.|..:||
Mouse   262 LPSGLSVSPQPSSIAPLRP 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	22/51 (43%)
Pdx1	NP_032840.1	Transactivation domain. /evidence=ECO:0000250	13..73		16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..116		24/123 (20%)
		Antp-type hexapeptide	119..124		0/4 (0%)
		Homeobox	150..203	CDD:278475	22/52 (42%)
		Nuclear localization signal	198..204		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..284		22/94 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910