Protein Alignment ey and Pax6

DIOPT Version :10

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_038655.1
• Gene: Pax6 / 18508
• MGIID: 97490
• Length: 436
• Species: Mus musculus
• Alignment Length: 596
• Identity: 253/596 - (42%)
• Similarity: 292/596 - (48%)
• Gaps: 207/596 - (34%)

  Fly    98 HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQ--------------VSNGCVSK 148
            ||||||||||||.||||||||||||||||||||||||||||||              ||||||||
Mouse     5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCVSK 69

  Fly   149 ILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSV 213
            |||||||||||||||||||||||||.||||||:|||||||||||||||||||.|.||||||||||
Mouse    70 ILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV 134

  Fly   214 SSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTA 278
            |||||||||||::|:|.
Mouse   135 SSINRVLRNLASEKQQM------------------------------------------------ 151

  Fly   279 TPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQ 343
                     ||         :.:|:|||:||.|..
Mouse   152 ---------GA---------DGMYDKLRMLNGQTG------------------------------ 168

  Fly   344 LVHGNHQALQQHQQQSWPPRHYSGSWYP-TSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDI 407
                           ||..|   ..||| ||:...|..
Mouse   169 ---------------SWGTR---PGWYPGTSVPGQPTQ--------------------------- 188

  Fly   408 ESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQ 472
                                     ||.|..|   |.|||:|..:||..::::.|.||.||||||
Mouse   189 -------------------------DGCQQQE---GGGENTNSISSNGEDSDEAQMRLQLKRKLQ 225

  Fly   473 RNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRR 537
            |||||||.:||::||||||||||||||||||||.||.||||||||||||||||||||||||||||
Mouse   226 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRR 290

  Fly   538 TPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSS-----PSTLSTNVN 597
            ..::|.:....||:.:|:.....|...:..||..|||..|.:.:.:....|     ||....| |
Mouse   291 QASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMAN-N 354

  Fly   598 APTLGAGIDSSESPTPIPHIRPSC---TSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGH 659
            .|        .:.|.|......||   ||.:.|||..:      :..|..:..|.|:..:.::|.
Mouse   355 LP--------MQPPVPSQTSSYSCMLPTSPSVNGRSYD------TYTPPHMQTHMNSQPMGTSGT 405

  Fly   660 AQGHALVPAIS 670
            .....:.|.:|
Mouse   406 TSTGLISPGVS 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	117/136 (86%)
		Homeodomain	473..528	CDD:459649	48/54 (89%)
Pax6	NP_038655.1	PAX	4..142	CDD:128645	117/136 (86%)
		Homeodomain	226..281	CDD:459649	48/54 (89%)