Protein Alignment ey and Pax5

DIOPT Version :10

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_032808.1
• Gene: Pax5 / 18507
• MGIID: 97489
• Length: 391
• Species: Mus musculus
• Alignment Length: 545
• Identity: 162/545 - (29%)
• Similarity: 214/545 - (39%)
• Gaps: 215/545 - (39%)

  Fly    98 HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPR 162
            |.||||||||||.||||||..||:||||||.|.|||||||.|:||:||||||||||||||||:|.
Mouse    17 HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPG 81

  Fly   163 AIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQK 227
            .||||||:|||.:||.||::|||:.|::||||||||||.|.||.||.:||||||||::|....|.
Mouse    82 VIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQP 146

  Fly   228 EQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNS 292
            ..|...:.|.|..:..|::         .||:|::.|.|:..|.:.::...:|        ::::
Mouse   147 PNQPVPASSHSIVSTGSVT---------QVSSVSTDSAGSSYSISGILGITSP--------SADT 194

  Fly   293 GEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQ 357
            .:....|.|.|
Mouse   195 NKRKRDEGIQE------------------------------------------------------ 205

  Fly   358 QSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVA 422
                                  |..||             .||| |..|.
Mouse   206 ----------------------SPVPN-------------GHSL-PGRDF--------------- 219

  Fly   423 TEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLE 487
                 |:|::.|                                         ..||..|::.|:
Mouse   220 -----LRKQMRG-----------------------------------------DLFTQQQLEVLD 238

  Fly   488 KEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTS 552
            :.|||.||.|:|.                           ..|.::.::.|..|..||.......
Mouse   239 RVFERQHYSDIFT---------------------------TTEPIKPEQTTEYSAMASLAGGLDD 276

  Fly   553 ATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTL------------STNVNAPTLGAGI 605
            ..|:|| ||......||:    .|..|...:.|....||.            ..:.:||||...:
Mouse   277 MKANLT-SPTPADIGSSV----PGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMV 336

  Fly   606 DSSE-SPTPIPHIRPSCTSDNDNGR 629
            ..|| |.:|..|  |..:|.||:.|
Mouse   337 PGSEFSGSPYSH--PQYSSYNDSWR 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	93/122 (76%)
		Homeodomain	473..528	CDD:459649	11/54 (20%)
Pax5	NP_032808.1	PAX	16..140	CDD:128645	93/122 (76%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		46/55 (84%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		32/47 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..218		11/133 (8%)
		Pax2_C	279..390	CDD:463563	26/88 (30%)