DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Nkx2-6

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_035050.2	Gene:	Nkx2-6 / 18092	MGIID:	97351	Length:	289	Species:	Mus musculus

Alignment Length:	289	Identity:	60/289 - (20%)
Similarity:	102/289 - (35%)	Gaps:	63/289 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 PISSAP-NIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSD--- 438
            |::|.| ::|.:....         ....|.::|:.....|| ||....:.:.:|....:|.
Mouse     5 PVASTPFSVADILRLE---------CQQKDSKTLSQWELHRN-PVKPRYLRMNQESGWFESSDRA 59

  Fly   439 -------------ETGS---GEGENSNG-----GASN------IGNTEDDQAR----LILKRKLQ 472
                         |.||   ||.:...|     ||.|      :||...|..|    ....|..:
Mouse    60 QAVPFRCTWETVLEMGSNPVGEPQTPPGTISRLGARNPMTDRGVGNLSGDMRRGGPVSTRTRPQR 124

  Fly   473 RNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRR 537
            ::|..|:..|:.:||:.|::..|.....||.||..:.|...::::||.|||.|    .|.:.|.:
Mouse   125 KSRVLFSQAQVLALERRFKQQRYLTAPEREHLASALQLTSTQVKIWFQNRRYK----SKSQRQDQ 185

  Fly   538 TPNSTGASATSSSTSATASLTD-------------SPNSLSACSSLLSGSAGGPSVSTINGLSSP 589
            |....|........:....:.|             .|...::..|...|.||.|..::.....:.
Mouse   186 TLELAGHPLAPRRVAVPVLVLDGKPCLDPDVAAFLGPYKATSPYSCFGGYAGTPYDASYASRCTS 250

  Fly   590 STLSTNVNAPTLGAGID-SSESPTPIPHI 617
            ::.......|...:|.. ..:|..|..|:
Mouse   251 ASAGPGPLTPLASSGFSPGGQSAAPQGHL 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	18/51 (35%)
Nkx2-6	NP_035050.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..125		13/49 (27%)
		Homeobox	126..179	CDD:278475	18/56 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..289		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910