DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and lim-4

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_508669.1	Gene:	lim-4 / 180672	WormBaseID:	WBGene00002987	Length:	355	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	92/392 - (23%)
Similarity:	142/392 - (36%)	Gaps:	108/392 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 SSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDL-MQTATPLNSSESGGASNSGEGSEQEA 300
            :||::..|.|:.....||..:|:.:..:...:|..::| ::...|.|...|        .|::.:
Worm    11 TSTASELSDSSLTFPFIGDYLSSPSLTTSDYVSDCSNLTVEGPVPANQEFS--------SSDESS 67

  Fly   301 IYEKLRLLNTQHAAGPGP---LEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQ---- 358
            :|....|....:|..|..   ::|.....:..|.                      |||.|
Worm    68 VYISSALRLADYAFTPDDNIRIKPDAVIVICTQC----------------------QHQIQDKFF 110

  Fly   359 -SWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASG----------PSLAHSLSP-----PNDI 407
             |...|:|..:....|..|.|:|:.......|.|..|          .|....|.|     ...|
Worm   111 LSIDGRNYHENCLQCSTCENPLSNKCFYKDKTFYCKGCYFRTHVTSTASSCRELGPKCASCDRTI 175

  Fly   408 ESLASIGHQRNCPVATEDIHL--------KKELDGHQSDETGSGEG------------ENSNGGA 452
            ::...:...||..     .||        |::|.  ..:|....||            |..:|.:
Worm   176 QATDWVRRARNYV-----YHLACFSCNQCKRQLS--TGEEYALQEGNLLCKQHFLELVEGDSGVS 233

  Fly   453 SNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQV 517
            |.             |.|.:|.||:|..||:..|:..|.|...||....|::|...||.:...||
Worm   234 SQ-------------KAKTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQV 285

  Fly   518 WFSNRRA---KWRREEKLRN---QRRT--PNSTGASATSSS-----TSATASLTDS-PNSLSACS 568
            ||.|.||   ||.::.:..|   ||.:  |:|....:.|||     ||.|.|:.|: |:|:....
Worm   286 WFQNSRARQKKWHQKSEGDNGDSQRSSVGPSSPSQKSDSSSEMMYPTSVTTSVEDAIPDSIVILG 350

  Fly   569 SL 570
            ||
Worm   351 SL 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	22/54 (41%)
lim-4	NP_508669.1	LIM	98..153	CDD:278823	15/76 (20%)
		LIM2_AWH	168..222	CDD:188765	10/60 (17%)
		HOX	239..295	CDD:197696	22/55 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940