DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Msx2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_038629.2	Gene:	Msx2 / 17702	MGIID:	97169	Length:	267	Species:	Mus musculus

Alignment Length:	324	Identity:	79/324 - (24%)
Similarity:	113/324 - (34%)	Gaps:	113/324 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 AGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIP 378
            ||||| .|..|.   |.:.......||.|..|    :||...::   ||:            |.|
Mouse    22 AGPGP-GPGGAE---GSAEERRVKVSSLPFSV----EALMSDKK---PPK------------ESP 63

  Fly   379 ISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSG 443
             :..|:.||     :|..|...|.|.:.:....|.|     |:.             :..||.|.
Mouse    64 -AVPPDCAS-----AGAVLRPLLLPGHGVRDAHSPG-----PLV-------------KPFETASV 104

  Fly   444 EGENSNGGASNI---GNTEDDQARL------ILKRKLQRN-RTSFTNDQIDSLEKEFERTHYPDV 498
            :.|||..||..|   |........:      :.|.|..|. ||.||..|:.:||::|.:..|..:
Mouse   105 KSENSEDGAPWIQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSI 169

  Fly   499 FARERLAGKIGLPEARIQVWFSNRRAKWRR-----EEKLRNQRRTPNSTGASATSSSTSATASLT 558
            ..|...:..:.|.|.::::||.|||||.:|     .|||:
Mouse   170 AERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLK------------------------- 209

  Fly   559 DSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESP-----TPIPHI 617
                  .|...:|      ||     |.|.|..    :|:|...|.|..:..|     .|||.:
Mouse   210 ------MAAKPML------PS-----GFSLPFP----INSPLQAASIYGASYPFHRPVLPIPPV 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	19/51 (37%)
Msx2	NP_038629.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..132		7/27 (26%)
		Homeobox	145..198	CDD:306543	19/52 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910