DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Hoxd11

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_032299.1	Gene:	Hoxd11 / 15431	MGIID:	96203	Length:	336	Species:	Mus musculus

Alignment Length:	296	Identity:	73/296 - (24%)
Similarity:	100/296 - (33%)	Gaps:	91/296 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 GGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAA----------PLVGQSPNHLGTRSSH 341
            ||....|.||...|.|         :||.......|.||          |..|:.|:.|   ...
Mouse    89 GGPGGGGGGSGGYAPY---------YAAAAAAAAAAAAAEEAAMQRDLLPPAGRRPDVL---FKA 141

  Fly   342 PQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTA--------------YA 392
            |:.|.|          ...||..             |.::|.|..|...              .|
Mouse   142 PEPVCG----------APGPPHG-------------PAAAASNFYSAVGRNGILPQGFDQFYEAA 183

  Fly   393 SGPSLA-----HSLSPP--------NDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGE 444
            .||..|     .:.:||        .|.:..|..|....|..||.....|...:|      |.||
Mouse   184 PGPPFAGPQPQPAPAPPQPEGAADKGDPKPGAGGGGGSPCAKATPGPEPKGAAEG------GGGE 242

  Fly   445 GENSNG--GASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGK 507
            ||...|  ||...|.|       :..::.::.|..:|..||..||:||....|.:...|.:|:..
Mouse   243 GEGPPGEAGAEKSGGT-------VAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRM 300

  Fly   508 IGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTG 543
            :.|.:.::::||.|||.|    ||..|:.|....||
Mouse   301 LNLTDRQVKIWFQNRRMK----EKKLNRDRLQYFTG 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	18/51 (35%)
Hoxd11	NP_032299.1	DUF3528	26..187	CDD:288866	27/132 (20%)
Hoxd11	NP_032299.1	Homeobox	267..320	CDD:278475	18/56 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910