DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Hoxd1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_034597.2	Gene:	Hoxd1 / 15429	MGIID:	96201	Length:	328	Species:	Mus musculus

Alignment Length:	381	Identity:	84/381 - (22%)
Similarity:	124/381 - (32%)	Gaps:	116/381 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 VSVSIGGNVSNVASGSRG------TLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRL 307
            ||.:.||....|.....|      ...:....:|.|.||         .||:|    |....|.|
Mouse     8 VSCAAGGGSGGVGGDVLGFAPKFCRADARPVALQPAFPL---------GSGDG----AFVSCLPL 59

  Fly   308 LNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSW--- 369
            .    .|.|.|..||..|    |||                   :.|.....:.|....|::
Mouse    60 A----TARPTPSPPAGPA----QSP-------------------VPQPAAPRYAPCTLEGAYERG 97

  Fly   370 -YPTSLSEIP-ISSAP-------------------NIASVTAYASGPSLAHSLSPPNDIESLASI 413
             .|.|.:|.. :.|.|                   :.|:...::.|.|..  ||...|..:....
Mouse    98 AAPASAAEYGFLGSGPAFDFPGALGRAADEGGAHVHYATSAVFSGGGSFL--LSGQVDFAAFGEP 160

  Fly   414 GHQRNCPVATEDIHLKKELDGH----QSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRN 474
            |....|        ||:..|||    |:.....|.........|::.........:.:||...:.
Mouse   161 GPFPAC--------LKEPADGHPGPFQTVSPAPGACPKPASPTSSLPAAHSTFEWMKVKRNAPKK 217

  Fly   475 ---------------RTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRA 524
                           ||:|:..|:..|||||....|.....|..:|..:.|.:.::::||.|||.
Mouse   218 SKLSEYGATSPPSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLQLNDTQVKIWFQNRRM 282

  Fly   525 KWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSG-SAGGPS 579
            |.::.|:          .|..||::|. |:..|..|..     |.:.|| :.|.||
Mouse   283 KQKKRER----------EGLLATAASV-ASIKLPRSET-----SPIKSGRNLGSPS 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	19/51 (37%)
Hoxd1	NP_034597.2	PRK04233	59..>105	CDD:305134	15/72 (21%)
		Antp-type hexapeptide	204..209		0/4 (0%)
		Homeobox	233..285	CDD:278475	19/51 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..328		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910