DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Hoxc4

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_038581.2	Gene:	Hoxc4 / 15423	MGIID:	96195	Length:	264	Species:	Mus musculus

Alignment Length:	317	Identity:	76/317 - (23%)
Similarity:	108/317 - (34%)	Gaps:	131/317 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 SPNHLG-TRSSHPQLVHGNHQALQQHQQQSWPP---------RHYS------------------G 367
            ||.:.| ||.|          ..|.|.|:.:||         |.||                  |
Mouse    33 SPEYYGRTRES----------GFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRAHGPAQAG 87

  Fly   368 SWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVA---TEDIHLK 429
            ..:|....  |:.....::..:|..|....|.|...|:...|.||     ..|:.   .:.||:
Mouse    88 HHHPEKSQ--PLCEPAPLSGTSASPSPAPPACSQPAPDHPSSAAS-----KQPIVYPWMKKIHV- 144

  Fly   430 KELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTH 494
                        |....|.|||                  :.:|:||::|..|:..|||||   |
Mouse   145 ------------STVNPNYNGG------------------EPKRSRTAYTRQQVLELEKEF---H 176

  Fly   495 YPDVFARER---LAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATAS 556
            |.....|.|   :|..:.|.|.:|::||.|||.||:::.:|      ||:...||..:.
Mouse   177 YNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRL------PNTKVRSAPPAG------ 229

  Fly   557 LTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTP 613
                                          ::|||||    |.|.|...|.|:|.||
Mouse   230 ------------------------------AAPSTLS----AATPGTSEDHSQSATP 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	23/54 (43%)
Hoxc4	NP_038581.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..130		23/108 (21%)
		Antp-type hexapeptide	135..140		0/4 (0%)
		Homeobox	159..213	CDD:365835	24/56 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..264		18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910