DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Hmx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_034575.1	Gene:	Hmx1 / 15371	MGIID:	107178	Length:	332	Species:	Mus musculus

Alignment Length:	287	Identity:	74/287 - (25%)
Similarity:	99/287 - (34%)	Gaps:	83/287 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 ATPLNSS----------ESGGASNSGEGS-------------EQEAIYEKLRLL--NTQHAAGPG 317
            |||..:|          |:.||..|.:|.             |.|...:..|.|  ..|..||.|
Mouse    11 ATPARASSFLIENLLAAEAKGAGRSTQGDGVREEEEEDDDDPEDEDPEQARRRLQRRRQQRAGSG 75

  Fly   318 PLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSA 382
            |...|||..|      .||.|   |....|...||.......|.||.:.|  |...||
Mouse    76 PGGEARARAL------GLGPR---PPPGPGPPFALGCGGTTRWYPRVHGG--YGGGLS------- 122

  Fly   383 PNIASVTAYASGPSL--AHSLSPPNDIESLASIGHQRNCP--------VATEDIHLKKELDGHQS 437
            |:.:...:..:|..:  |.|..|              .||        |.|            |.
Mouse   123 PDTSDRDSPETGEEMGRAESAWP--------------RCPGPGTVPREVTT------------QG 161

  Fly   438 DETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARE 502
            ..|| ||.......|..:......:||   ..:.::.||.|:..|:..||..|:...|.....|.
Mouse   162 PATG-GEEAAELAEAPAVAAAATGEAR---GGRRKKTRTVFSRSQVFQLESTFDLKRYLSSAERA 222

  Fly   503 RLAGKIGLPEARIQVWFSNRRAKWRRE 529
            .||..:.|.|.::::||.|||.||:|:
Mouse   223 GLAASLQLTETQVKIWFQNRRNKWKRQ 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	19/51 (37%)
Hmx1	NP_034575.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..170		46/186 (25%)
		Homeobox	194..247	CDD:278475	19/52 (37%)
		HMX family specific domain 1	251..261
		HMX family specific domain 2	264..277
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910