DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and GSC

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_776248.1	Gene:	GSC / 145258	HGNCID:	4612	Length:	257	Species:	Homo sapiens

Alignment Length:	202	Identity:	60/202 - (29%)
Similarity:	95/202 - (47%)	Gaps:	30/202 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 GSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKE 431
            |::||.     |:  ||..|.:.|..||..|.::......:       |.:..||..........
Human    55 GAFYPR-----PV--APGGAGLPAAVSGSRLGYNNYFYGQL-------HVQAAPVGPACCGAVPP 105

  Fly   432 LDGHQSDETGSGEGENSNGGA------------SNIGNTEDDQARLILK---RKLQRNRTSFTND 481
            |...|.....:..|....|..            .|:|.....:.:|:.:   |:.:|:||.||::
Human   106 LGAQQCSCVPTPPGYEGPGSVLVSPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDE 170

  Fly   482 QIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASA 546
            |:::||..|:.|.||||..||:||.|:.|.|.:::|||.|||||||| :|..:...:.|:...:.
Human   171 QLEALENLFQETKYPDVGTREQLARKVHLREEKVEVWFKNRRAKWRR-QKRSSSEESENAEKWNK 234

  Fly   547 TSSSTSA 553
            ||||.::
Human   235 TSSSKAS 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	28/51 (55%)
GSC	NP_776248.1	Homeobox	163..216	CDD:306543	28/52 (54%)
GSC	NP_776248.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..257		11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940