DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and CRX

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_000545.1	Gene:	CRX / 1406	HGNCID:	2383	Length:	299	Species:	Homo sapiens

Alignment Length:	276	Identity:	88/276 - (31%)
Similarity:	128/276 - (46%)	Gaps:	55/276 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 RKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLR 533
            ||.:|.||:||..|::.||..|.:|.||||:|||.:|.||.|||:|:||||.|||||.|::.:.:
Human    37 RKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQ 101

  Fly   534 NQRRTPNSTGASA----TSSSTSATASLTDSPNSLSACSSL---LSGSAGGP--SVSTINGLSSP 589
            .|::.|....|.|    ..:.||...|....|:.|....|.   |.|.:|.|  :|:|:: :.||
Human   102 KQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVS-IWSP 165

  Fly   590 STLSTNVNAPTLGAGIDSSESPTPIPH---IRPS---CTSDNDNGRQS---EDCRRVCSPCPLGV 645
            ::.|....|...|. :.|..|.|..|:   ..|:   |:|.:..|..|   .......||....:
Human   166 ASESPLPEAQRAGL-VASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQL 229

  Fly   646 GGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPS---- 706
            ||                   ||:||   .:..|.|...: ...|:|| ..||||.:|:.|
Human   230 GG-------------------PALSP---LSGPSVGPSLA-QSPTSLS-GQSYGAYSPVDSLEFK 270

  Fly   707 -------FNHSAVGPL 715
                   |.::.:.||
Human   271 DPTGTWKFTYNPMDPL 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
CRX	NP_000545.1	Homeobox	43..93	CDD:395001	30/49 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..155		16/61 (26%)
		TF_Otx	166..249	CDD:397546	22/106 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910