DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and Dmbx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_017175446.1	Gene:	Dmbx1 / 140477	MGIID:	2153518	Length:	389	Species:	Mus musculus

Alignment Length:	378	Identity:	102/378 - (26%)
Similarity:	143/378 - (37%)	Gaps:	134/378 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 RKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRR----- 528
            ||.:|:||:||..|:::|||.|::||||||..|||||....|||||:||||.|||||:|:
Mouse    77 RKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSL 141

  Fly   529 -EEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTL 592
             :|:|:.|:....|.|.....:..|.|...|:.|..|         .:|.|.......||..|
Mouse   142 QKEQLQKQKEAEGSHGEGKVEAPASDTQLETEQPPGL---------PSGDPPAELQLSLSEQS-- 195

  Fly   593 STNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSN 657
                          :|||       .|....|.:...::|:.:...||      |.::.
Mouse   196 --------------ASES-------APEDQLDREEDSRAEEPKAEKSP------GSESK------ 227

  Fly   658 GHAQGHALVPAI---SPRLNFNSGSFGAMYSNMHHTALSMSDSYG--AVTPI--------PSFNH 709
                    ||..   ||:                      :||.|  |:||.        ||.::
Mouse   228 --------VPGCKRGSPK----------------------ADSPGSLAITPAAPGGGLLGPSHSY 262

  Fly   710 SAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAP---AHHHIVPGDGGRPAGVGLGSGQSAN 771
            |:                :|.||:......|....|.   .|:......|..||.....:.....
Mouse   263 SS----------------SPLSLFRLQEQFRQHMAATNNLMHYSSFEVGGPAPAAAAAAAAAVPY 311

  Fly   772 LGAS--------CSGSGYEVLSAYA-----------LPPPP--MASSSAADSS 803
            ||.:        |. |.|:.|||.|           ||.||  :|.:|||.:|
Mouse   312 LGVNMAPLSSLHCQ-SYYQSLSAAAAAHQGVWGSPLLPAPPTGLAPASAALNS 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	34/51 (67%)
Dmbx1	XP_017175446.1	Homeobox	82..136	CDD:365835	34/53 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940