DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Dlx3

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_034185.1	Gene:	Dlx3 / 13393	MGIID:	94903	Length:	287	Species:	Mus musculus

Alignment Length:	404	Identity:	76/404 - (18%)
Similarity:	137/404 - (33%)	Gaps:	160/404 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 HLGTRSSHPQLVHG-----NHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPN---IASVTA 390
            |.|::.| |.|...     .:.:..||.       :|||..|..:::........|   :|...|
Mouse    23 HAGSKDS-PTLPESTVTDLGYYSAPQHD-------YYSGQPYGQTVNPYTYHHQFNLNGLAGTGA 79

  Fly   391 YASGPSLAHSLSPPNDIE---SLASIGHQRNCPVATED-IHLKKELDGHQSDETGSGEGENSNGG 451
            |          ||.::..   |....|..|..|:..:| :.:|:|
Mouse    80 Y----------SPKSEYTYGGSYRQYGAYREQPLPAQDPVSVKEE-------------------- 114

  Fly   452 ASNIGNTEDDQARLI--LKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEAR 514
                   .:.:.|::  ..:|:::.||.:::.|:.:|::.|::..|..:..|..||.::||.:.:
Mouse   115 -------PEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQ 172

  Fly   515 IQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPS 579
            :::||.|||:|::   ||......|                 |..|||:   ..|:...|...|:
Mouse   173 VKIWFQNRRSKFK---KLYKNGEVP-----------------LEHSPNN---SDSMACNSPPSPA 214

  Fly   580 VSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPH-IRPSCTSDNDNGRQSEDCRRVCSPCPL 643
            :...:..|:|        ||.      .:..|.|:|: ..|:...|..|
Mouse   215 LWDTSSHSTP--------APA------RNPLPPPLPYSASPNYLDDPTN---------------- 249

  Fly   644 GVGGHQNTHHIQ--SNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPS 706
                  :.:|.|  |..|.|.....||                                     :
Mouse   250 ------SWYHTQNLSGPHLQQQPPQPA-------------------------------------T 271

  Fly   707 FNHSAVGPLAPPSP 720
            .:|::.||  ||:|
Mouse   272 LHHASPGP--PPNP 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	17/51 (33%)
Dlx3	NP_034185.1	DLL_N	27..107	CDD:315147	19/97 (20%)
		Abdominal-A	<109..224	CDD:332641	32/164 (20%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:O60479	131..181		14/49 (29%)
		Homeobox	132..185	CDD:306543	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..287		30/167 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910