DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and Crx

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001106801.1	Gene:	Crx / 12951	MGIID:	1194883	Length:	323	Species:	Mus musculus

Alignment Length:	382	Identity:	101/382 - (26%)
Similarity:	148/382 - (38%)	Gaps:	134/382 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 TSLSEIPISSAPNIASVTAYAS-GPSL---AHSLSPPNDIESLASIGHQRNCPVATEDIHLKKEL 432
            |:||::|.|...::..:.||.: ||..   |.:||.||     ..:.||. .|.::
Mouse     9 TALSKVPSSGPQSLKIMMAYMNPGPHYSVNALALSGPN-----VDLMHQA-VPYSS--------- 58

  Fly   433 DGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPD 497
                                              ..||.:|.||:||..|::.||..|.:|.|||
Mouse    59 ----------------------------------APRKQRRERTTFTRSQLEELEALFAKTQYPD 89

  Fly   498 VFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPN 562
            |:|||.:|.||.|||:|:||||.|||||.|::.:.:.|::.|  .||...:......|..:..|
Mouse    90 VYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQP--PGAQTKARPAKRKAGTSPRP- 151

  Fly   563 SLSACSSLL------SGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIR--- 618
            |...|:..|      |.|..|||       .||:|....|:       |.|..|..|:|..:
Mouse   152 STDVCTDPLGISDSYSPSLPGPS-------GSPTTAVATVS-------IWSPASEAPLPEAQRAG 202

  Fly   619 -----PSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAI--SPRLNFN 676
                 ||.||               :|                  :|..:|...|.  ||....:
Mouse   203 LVASGPSLTS---------------AP------------------YAMTYAPASAFCSSPSAYAS 234

  Fly   677 SGSFGAMYSNMHHTALSMSDSYGAVTP-IPSFNHSAVGPLAPPSPIPQQGDLTPSSL 732
            ..|:   :|.:        |.|  ::| :|.....|:.||:.||..|.... :|:||
Mouse   235 PSSY---FSGL--------DPY--LSPMVPQLGGPALSPLSGPSVGPSLAQ-SPTSL 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
Crx	NP_001106801.1	Homeobox	67..117	CDD:278475	30/49 (61%)
Crx	NP_001106801.1	TF_Otx	188..273	CDD:281521	26/131 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910