DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and DMBX1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001374705.1	Gene:	DMBX1 / 127343	HGNCID:	19026	Length:	382	Species:	Homo sapiens

Alignment Length:	390	Identity:	105/390 - (26%)
Similarity:	148/390 - (37%)	Gaps:	138/390 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 RKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRR----- 528
            ||.:|:||:||..|:::|||.|::||||||..|||||....|||||:||||.|||||:|:
Human    69 RKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSL 133

  Fly   529 -EEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTL 592
             :|:|:.|:....|.|.....:.|..|...|:.|..|.                   |...|:.|
Human   134 QKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLP-------------------GSDPPAEL 179

  Fly   593 STNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSN 657
            ..:::..:      :|||   .|..:|....|...|  :||.:...||
Human   180 HLSLSEQS------ASES---APEDQPDREEDPRAG--AEDPKAEKSP----------------- 216

  Fly   658 GHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIP 722
                     .|.|..|....||             ..:||.|::|         :.|:||..
Human   217 ---------GADSKGLGCKRGS-------------PKADSPGSLT---------ITPVAPGG--- 247

  Fly   723 QQGDLTPSSLYPC--------------HMTLR-------------PPPMAPAHHHIVPGDGGRPA 760
              |.|.||..|..              ||...             |.|.|.|....||     ..
Human   248 --GLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVP-----YL 305

  Fly   761 GVGLGSGQSANLGASCSGSGYEVLSAYA-----------LPPPPMASSSAADSSFSAASSASANV 814
            ||.:     |.||:....|.|:.|||.|           ||.|| |..:.|.::.::.:::..|:
Human   306 GVNM-----APLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPP-AGLAPASATLNSKTTSIENL 364

Fly 815 814
Human 365 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	34/51 (67%)
DMBX1	NP_001374705.1	Interaction with OTX2 and is required for repressor activity. /evidence=ECO:0000250\|UniProtKB:Q91ZK4	1..156		43/86 (50%)
		Homeobox	74..128	CDD:395001	34/53 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..252		38/206 (18%)
		OAR	357..373	CDD:397759	1/8 (13%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	359..372		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940