Protein Alignment ey and Pax3

DIOPT Version :10

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_446162.1
• Gene: Pax3 / 114502
• RGDID: 620431
• Length: 484
• Species: Rattus norvegicus
• Alignment Length: 772
• Identity: 218/772 - (28%)
• Similarity: 284/772 - (36%)
• Gaps: 341/772 - (44%)

  Fly   101 VNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIG 165
            ||||||||:.|||||:..|.||||:||.|.|||.|||.|:||:|||||||.||.|||||||.|||
  Rat    38 VNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIG 102

  Fly   166 GSKPR-VATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQ 229
            ||||: |.|.:|..||.:||||.|.:|:|||||:||::.||..:.:||||||:|:||
  Rat   103 GSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR-------- 159

  Fly   230 QSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGE 294
                                                                        |..|:
  Rat   160 ------------------------------------------------------------SKFGK 164

  Fly   295 GSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQS 359
            |.|:||..|:..
  Rat   165 GEEEEADLERKE----------------------------------------------------- 176

  Fly   360 WPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATE 424
                                          |..|.....||:
  Rat   177 ------------------------------AEESEKKAKHSI----------------------- 188

  Fly   425 DIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKE 489
            |..|.:.....||||                |:..|.:..|.||||.:|:||:||.:|::.||:.
  Rat   189 DGILSERASAPQSDE----------------GSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERA 237

  Fly   490 FERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSAT 554
            ||||||||::.||.||.:..|.|||:|||||||||:||::            .||
  Rat   238 FERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQ------------AGA---------- 280

  Fly   555 ASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHI-- 617
                   |.|.|.:.|:.|  |.|          |:.:.|   .||.... ::|..||.||..
  Rat   281 -------NQLMAFNHLIPG--GFP----------PTAMPT---LPTYQLS-ETSYQPTSIPQAVS 322

  Fly   618 RPSCTSDNDNGRQSEDCRRVCSPCPLGVGG-HQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFG 681
            .||.|              |..|.||.... ||:|  |.||..:.....:|  |.|..|:
  Rat   323 DPSST--------------VHRPQPLPPSTVHQST--IPSNADSSSAYCLP--STRHGFS----- 364

  Fly   682 AMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAP 746
                       |.:||:                 .|||        .||:           ||.|
  Rat   365 -----------SYTDSF-----------------VPPS--------GPSN-----------PMNP 382

  Fly   747 AHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPP-----PPMASSSAADSSFSA 806
            |     .|:|..|..:||    ..|.|    |..::..:.|||.|     .|..:.||   |.|.
  Rat   383 A-----IGNGLSPQVMGL----LTNHG----GVPHQPQTDYALSPLTGGLEPTTTVSA---SCSQ 431

  Fly   807 ASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISP-AVSSYAHMSYNY 862
            ......||....| :|..||...|         ::|:|.||::. ....|...:::|
  Rat   432 RLEHMKNVDSLPT-SQPYCPPTYS---------TTGYSMDPVTGYQYGQYGQSAFHY 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	80/120 (67%)
		Homeodomain	473..528	CDD:459649	34/54 (63%)
Pax3	NP_446162.1	PAX	34..159	CDD:128645	80/120 (67%)
		Homeodomain	220..276	CDD:459649	34/55 (62%)
		Pax7	347..391	CDD:403540	19/102 (19%)