DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and LDB3

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001165081.1	Gene:	LDB3 / 11155	HGNCID:	15710	Length:	732	Species:	Homo sapiens

Alignment Length:	704	Identity:	144/704 - (20%)
Similarity:	217/704 - (30%)	Gaps:	214/704 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 NIPSVSSINRVLRNLAAQKEQQSTGS-----GSSSTSAGNSISAKVSV-SIGGNVSNVASGSRGT 267
            |:|  .:|:|:.....|.:.|.|.|.     ...:|.....:.|:..: |...|:|.....|:..
Human    24 NMP--LTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRP 86

  Fly   268 LSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHA-AGPGPLEPARAAPLVGQS 331
            :..||......|||                ....::|...|:|..: ..|.|...|||:|
Human    87 IPISTTAPPVQTPL----------------PVIPHQKDPALDTNGSLVAPSPSPEARASP----- 130

  Fly   332 PNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPS 396
                ||..: |:|            :.::.|.....|.: :||:|......|. ||:.|..| |.
Human   131 ----GTPGT-PEL------------RPTFSPAFSRPSAF-SSLAEASDPGPPR-ASLRAKTS-PE 175

  Fly   397 LAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKEL-DGHQSDETGSGEGENSNGGASNIGNTED 460
            .|..|..|..:.. :|...|.|.|:........:|: ..:|....|...|....|||       |
Human   176 GARDLLGPKALPG-SSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGA-------D 232

  Fly   461 DQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAK 525
            .|.|.        |.::..:..:.        ||.|  ...:.|.||..:..|
Human   233 YQERF--------NPSALKDSALS--------THKP--IEVKGLGGKATIIHA------------ 267

  Fly   526 WRREEKLRNQRRTP---NSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLS 587
                     |..||   .|..|...:.:..|.|..:|...|| ....|...||.....:.|...:
Human   268 ---------QYNTPISMYSQDAIMDAIAGQAQAQGSDFSGSL-PIKDLAVDSASPVYQAVIKSQN 322

  Fly   588 SP-------STLSTNVNAPTLG-----AGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSP 640
            .|       :..|:|:.:.:..     .|.:..:.|            |.:..|:|.......||
Human   323 KPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDP------------DEEALRRSRPQASSYSP 375

  Fly   641 CPLGVGGHQNTHHIQSNGHAQGHALVPAISPRL----------------NFNSGSFGAMYSNMHH 689
            . :.......||...|.|.|     .||..||:                :..|.|.||.||...:
Human   376 A-VAASSAPATHTSYSEGPA-----APAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPY 434

  Fly   690 TALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPG 754
            |.          :|.|::..|. .|...|||:|   ..|||.. |.:.....|...||......|
Human   435 TP----------SPAPAYTPSP-APAYTPSPVP---TYTPSPA-PAYTPSPAPNYNPAPSVAYSG 484

  Fly   755 DGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHT 819
            ....||.                             .||..:    |.|||...:...:.|   :
Human   485 GPAEPAS-----------------------------RPPWVT----DDSFSQKFAPGKSTT---S 513

  Fly   820 IAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYAS--SANTMTP 871
            |::::.|             ..|.:..|..|.|...|..:...|.  .|::.||
Human   514 ISKQTLP-------------RGGPAYTPAGPQVPPLARGTVQRAERFPASSRTP 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	4/11 (36%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	7/51 (14%)
LDB3	NP_001165081.1	PDZ_signaling	5..81	CDD:238492	13/58 (22%)
		DUF4045	<77..180	CDD:330572	32/143 (22%)
		ZM	189..214	CDD:128974	5/24 (21%)
		DUF4749	263..353	CDD:318205	19/111 (17%)
		Atrophin-1	<387..554	CDD:331285	48/235 (20%)
		LIM1_ZASP_Cypher	556..607	CDD:188838
		LIM2_Enigma_like	615..666	CDD:188748
		LIM3_Enigma_like	674..727	CDD:188749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030