DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Lmx1a

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_387501.1	Gene:	Lmx1a / 110648	MGIID:	1888519	Length:	382	Species:	Mus musculus

Alignment Length:	268	Identity:	59/268 - (22%)
Similarity:	98/268 - (36%)	Gaps:	89/268 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 NIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENS 448
            ::.|..|..||.|        :|.|||....|                         |:|:|.:.
Mouse   156 SLVSPAASDSGKS--------DDEESLCKSAH-------------------------GAGKGASE 187

  Fly   449 NGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEA 513
            :|        :|       .::.:|.||..|..|..:.:..||.:..|....||.||.:.||...
Mouse   188 DG--------KD-------HKRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVR 237

  Fly   514 RIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGP 578
            .:||||.|:|||.::..:.:.|::.........||:.|:.                  ||:||
Mouse   238 VVQVWFQNQRAKMKKLARRQQQQQQDQQNTQRLTSAQTNG------------------SGNAG-- 282

  Fly   579 SVSTINGLSSP-STLSTNVNAPTLGAGIDSSE------SPTPIP--HIRP--------SCTSDND 626
                :.|:.:| :||.|......:...:.:|:      :|..:|  |:.|        ...||:.
Mouse   283 ----MEGIMNPYTTLPTPQQLLAIEQSVYNSDPFRQGLTPPQMPGDHMHPYGAEPLFHDLDSDDT 343

  Fly   627 NGRQSEDC 634
            :.....||
Mouse   344 SLSNLGDC 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	21/51 (41%)
Lmx1a	NP_387501.1	LIM1_Lmx1a	35..86	CDD:188756
		LIM2_Lmx1a_Lmx1b	94..148	CDD:188764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..208		19/94 (20%)
		Homeobox	198..252	CDD:365835	21/53 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..286		8/57 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910