DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ey and DUX4

DIOPT Version :9

Sequence 1:NP_001014693.1 Gene:ey / 43812 FlyBaseID:FBgn0005558 Length:898 Species:Drosophila melanogaster
Sequence 2:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens


Alignment Length:402 Identity:105/402 - (26%)
Similarity:143/402 - (35%) Gaps:95/402 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   472 QRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAK----WRREEKL 532
            :|.|..:|..|.::|...|||..||.:..|||||..||:||.|:|:||.|.|::    .|||.:.
Human    20 RRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRP 84

  Fly   533 RNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVN 597
            ...||.|.......|:.:.|.||.|      |.|...           ....|:::...|:....
Human    85 WPGRRGPPEGRRKRTAVTGSQTALL------LRAFEK-----------DRFPGIAAREELARETG 132

  Fly   598 APTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQ-SNGHAQ 661
            .|         ||...|.............||.......:||..|  .|||.....:. ::..|.
Human   133 LP---------ESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAP--GGGHPAPSWVAFAHTGAW 186

  Fly   662 GHALVPAISPRLNFNSGSF--GAMYSNMHHTALSMSDSY-----GAVTPIPSFNHSAVGPLAPPS 719
            |..| ||  |.:....|:.  ||..|.....|.::..|.     |...|.|     |.|..|..:
Human   187 GTGL-PA--PHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAP-----ARGDFAYAA 243

  Fly   720 PIPQQGDLT--PSSLYPCHMTLR-----------PPPMAPAHHHIVPGDG-GRPAGVGL------ 764
            |.|..|.|:  .:..:|.|....           |.|.|.|.    ||.. ..|.|.|:      
Human   244 PAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQ----PGPAQAGPQGQGVLAPPTS 304

  Fly   765 ------GSGQSANLGASCSGSGYEVLSAYALPP---PPMASSSAADSSFSAASSASANVTPHHTI 820
                  |.|:    |...:|:.:|..:..|.||   ||.||:||.........:.|..:      
Human   305 QGSPWWGWGR----GPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQAL------ 359

  Fly   821 AQESCP---SPC 829
             ||..|   .||
Human   360 -QEPAPWSALPC 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eyNP_001014693.1 PAX 98..221 CDD:128645
Homeobox 475..527 CDD:278475 24/55 (44%)
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 1/3 (33%)
Homeobox 27..74 CDD:306543 23/46 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102 7/29 (24%)
Homeobox 97..149 CDD:306543 13/77 (17%)
DNA_pol3_gamma3 <141..319 CDD:331207 44/195 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 38/163 (23%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 15/51 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0849
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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