Protein Alignment ey and pax3b

DIOPT Version :10

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_001315326.1
• Gene: pax3b / 100150137
• ZFINID: ZDB-GENE-080917-53
• Length: 469
• Species: Danio rerio
• Alignment Length: 767
• Identity: 212/767 - (27%)
• Similarity: 286/767 - (37%)
• Gaps: 346/767 - (45%)

  Fly   101 VNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIG 165
            ||||||||:.|||||:..|.||||:||.|.|||.|||.|:||:|||||||.||.|||||||.|||
Zfish    38 VNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIG 102

  Fly   166 GSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQ 230
            |:|.:..:.:|..::.:||||.|.||:|||||:||:|.:|..:|:|:||||:|::|.
Zfish   103 GTKSKTTSPDVEKRVEEYKRENPGIFSWEIRDKLLKEGICDRNNVPTVSSISRIMRG-------- 159

  Fly   231 STGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEG 295
                                          .||:|                       |....|.
Zfish   160 ------------------------------RSGTR-----------------------ADEEEEE 171

  Fly   296 SEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSW 360
            .::|.|..:.|..|.                       |.|
Zfish   172 EDEEDIERREREENA-----------------------HRG------------------------ 189

  Fly   361 PPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATED 425
                                                 |||      ||.:.:   .|:.|
Zfish   190 -------------------------------------AHS------IEGILA---DRSSP----- 203

  Fly   426 IHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEF 490
                       |||                |:..:.:..|.||||.:|:||:||.||::.||:.|
Zfish   204 -----------SDE----------------GSEVESEPDLPLKRKQRRSRTTFTADQLEELERAF 241

  Fly   491 ERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATA 555
            |||||||::.||.||.:..|.|||:|||||||||:||::            .||
Zfish   242 ERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQ------------AGA----------- 283

  Fly   556 SLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPS 620
                  |.|.|.:.|:.|.....::|::    ||..|               ||||.| |...|
Zfish   284 ------NQLMAFNHLIPGGFSHHAMSSL----SPYQL---------------SESPYP-PAALP- 321

  Fly   621 CTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHA--QGHALVPAISPRLNFNSGSFGAM 683
                       :|...|..|.||....|      ||:|.|  :|                  ||.
Zfish   322 -----------QDSGTVHRPQPLPHSSH------QSSGGAGPEG------------------GAS 351

  Fly   684 YS-NMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQ--GDLTPSSLYPCHMTLRPPPMA 745
            |. :..|.....||::|   |..:.|::|:.     :.:..|  |.:|||.  ..|.|
Zfish   352 YCLSSRHGYTGYSDAFG---PHNTHNNNAIN-----NGLSSQVMGLITPSG--ASHPT------- 399

  Fly   746 PAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSA 810
                         .|...|.||.|  :.:||| ...|.||  :||                   |
Zfish   400 -------------QAEFSLDSGSS--VSSSCS-QRMESLS--SLP-------------------A 427

  Fly   811 SANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNY 862
            .:|:         |.|...||||.:.:.||..:.       .|.|...|::|
Zfish   428 LSNL---------SNPQSYSSASFYSLEHSGHYQ-------YSQYGQNSFHY 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	75/119 (63%)
		Homeodomain	473..528	CDD:459649	35/54 (65%)
pax3b	NP_001315326.1	PAX	34..158	CDD:366005	75/119 (63%)
		Homeodomain	223..279	CDD:459649	35/55 (64%)
		Pax7	346..385	CDD:403540	11/64 (17%)