DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and nkx2-5

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001116891.1	Gene:	nkx2-5 / 100144646	XenbaseID:	XB-GENE-487966	Length:	300	Species:	Xenopus tropicalis

Alignment Length:	310	Identity:	62/310 - (20%)
Similarity:	111/310 - (35%)	Gaps:	99/310 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 LQQHQQQSWP----PRHYSGSWYPTSLSEIPISSAPNIASVTA------YASGPS---------- 396
            |:|||....|    .|..:.|...::..:.|....|.::.:|.      .:.|||
Frog    19 LEQHQSGLSPMDITSRLENSSCMLSTFKQEPYPGTPCLSELTEELAQRDSSKGPSPFPGSFFVKN 83

  Fly   397 ---LAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNT 458
               :..|..|.:|.:.:        ||:.....|.|:|.:
Frog    84 YLEMDSSKDPKDDKKDI--------CPLQKTLEHDKREAE------------------------- 115

  Fly   459 EDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRR 523
            :.::.|   :||.::.|..|:..|:..||:.|::..|.....|:.||..:.|...::::||.|||
Frog   116 DPERPR---QRKRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRR 177

  Fly   524 AKWRREEK--------LRNQRR---------------------TPNSTGASATSSSTSATASLTD 559
            .|.:|:.:        |...||                     :|.:...:..|.:|....|...
Frog   178 YKCKRQRQDQTLEMVGLPPPRRIAVPVLVRDGKPCLGESSPYNSPYNVSINPYSYNTYPAYSNYS 242

  Fly   560 SPN-------SLSACSSLLSGSAGGP----SVSTINGLSSPSTLSTNVNA 598
            :|.       |.|:..|:...|||..    ||..:|.:.:|...::.|:|
Frog   243 NPACSGSYNCSYSSMPSMQPTSAGNNFMNFSVGDLNTVQTPIQQASGVSA 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	17/51 (33%)
nkx2-5	NP_001116891.1	Homeobox	132..182	CDD:365835	16/49 (33%)
nkx2-5	NP_001116891.1	COG5576	<133..235	CDD:227863	21/101 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910