DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and nkx2-6

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_002932599.1	Gene:	nkx2-6 / 100038094	XenbaseID:	XB-GENE-486951	Length:	254	Species:	Xenopus tropicalis

Alignment Length:	263	Identity:	64/263 - (24%)
Similarity:	101/263 - (38%)	Gaps:	65/263 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 PISSAP-NIASVTAYASG-----PSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGH- 435
            |.:|.| ::..:....:|     |..:|..:.|      ..||..|..|:..:     :|..|.
Frog     5 PATSTPFSVKDILRLENGQVGSAPVRSHPGTDP------LLIGAARRDPIERD-----RESPGAF 58

  Fly   436 -QS----DETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHY 495
             ||    |...:.|.....||....|..|.     :..|:.::.|..|:..|:..||:.|::..|
Frog    59 CQSPQIEDPDFAQEQSGYFGGLGRGGPQEQ-----LHHRQRRKPRVLFSQMQVFELERRFKQQRY 118

  Fly   496 PDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRN--------QRRT-------------- 538
            .....||:||..:.|...::::||.|||.|.:|:::.|:        .||.
Frog   119 LSAPEREQLALALKLTSTQVKIWFQNRRYKCKRQKQDRSLELGHPIPPRRVAVPVLVRDGKPCLG 183

  Fly   539 PNSTGASATSSSTSATASLTDSPNSLSACSSLLSGS---AGGPSVSTINGLSSPSTLSTNVNAPT 600
            |..|.||  ..:.|||      |.:...|....:.|   :|.|||.|:..    ..:|.|..|..
Frog   184 PTQTFAS--PYNVSAT------PYTYPVCYGNYTNSPYYSGAPSVPTMGS----QLISMNTTAVP 236

  Fly   601 LGA 603
            .||
Frog   237 SGA 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	18/51 (35%)
nkx2-6	XP_002932599.1	Homeobox	97..151	CDD:365835	18/53 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910