Protein Alignment myo and GDF15

DIOPT Version :10

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_004855.2
• Gene: GDF15 / 9518
• HGNCID: 30142
• Length: 308
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 71/357 - (19%)
• Similarity: 127/357 - (35%)
• Gaps: 96/357 - (26%)

  Fly   287 MQGDDANTVN--EFLI------------DLNKNQAKKSDIP----INTNDEEYESILSHISSIYI 333
            |.|.:..|||  :.|:            .|:..:|.::..|    :::.|..:..:....
Human     1 MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY----- 60

  Fly   334 FPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATL--------------HLYLRGWDWISAHQPGL 384
              |::...:|.|:       ..:.|.:||..|..              ||:||    ||  :..|
Human    61 --EDLLTRLRANQ-------SWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLR----IS--RAAL 110

  Fly   385 LEEIKKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQW-VAVDLKSLLGNLGSNM 448
            .|.:.:..|      :|||:                ||.| |:....| |...|:..| :|....
Human   111 PEGLPEASR------LHRAL----------------FRLS-PTASRSWDVTRPLRRQL-SLARPQ 151

  Fly   449 TQEILIKGAETWMKSLVVTTDNTSKNP-LTVHIEIGSQKKHRRKRSVYMDCTENDH----DMRCC 508
            ...:.::.:....:|..:..:::|..| |.:|:...:.:..||.|:     ...||    ..|||
Human   152 APALHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARA-----RNGDHCPLGPGRCC 211

  Fly   509 R-YPLKVNFTSFGW-HFVVAPTSFDAYFCSGDCKVGYLEQYPHT------HLAALTTSATPCCSP 565
            | :.::.:....|| .:|::|.......|.|.|...:.....|.      |.....|...|||.|
Human   212 RLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVP 276

  Fly   566 TKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSC 597
            ...:.:.|:...|. .:.|....::..:.|.|
Human   277 ASYNPMVLIQKTDT-GVSLQTYDDLLAKDCHC 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	22/98 (22%)
GDF15	NP_004855.2	PRK10929	<23..>147	CDD:236798	31/167 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..177		2/24 (8%)
		TGF_beta_GDF15	208..307	CDD:381646	22/99 (22%)