DRSC/TRiP Functional Genomics Resources

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Protein Alignment myo and GDF5

DIOPT Version :10

Sequence 1:NP_726604.1 Gene:myo / 43811 FlyBaseID:FBgn0026199 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_000548.2 Gene:GDF5 / 8200 HGNCID:4220 Length:501 Species:Homo sapiens


Alignment Length:399 Identity:94/399 - (23%)
Similarity:141/399 - (35%) Gaps:131/399 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   261 ESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTNDEEYESIL 325
            |..||:..|..|   .|....:||.:::...|||:..|   ::|.|                   
Human   171 EYMLSLYRTLSD---ADRKGGNSSVKLEAGLANTITSF---IDKGQ------------------- 210

  Fly   326 SHISSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSD-LSYATLHL-------------------- 369
                      ::..|.||..|.|    |.|.:...| |..|.|.:                    
Human   211 ----------DDRGPVVRKQRYV----FDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAA 261

  Fly   370 YLRGWDWISAHQPGLLEEIKKQPRKD----IVVTIHRAIRVANTTSFNPKVKMFEFRHS--IPSG 428
            .|:.....|..||..|.:::..|..|    .|..|.:..|              .|::|  :...
Human   262 QLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDIWKLFR--------------NFKNSAQLCLE 312

  Fly   429 LGQWV---AVDLKSLLGNLGSNMTQEILIKGAETWMKSLVVTTDNTSKNPL-------------- 476
            |..|.   ||||:.|..:..:....|          |:|.:....|.|..|              
Human   313 LEAWERGRAVDLRGLGFDRAARQVHE----------KALFLVFGRTKKRDLFFNEIKARSGQDDK 367

  Fly   477 TVHIEIGSQKKHRR--------KRSVYMDCTENDHDMRCCRYPLKVNFTSFGW-HFVVAPTSFDA 532
            ||:..:.||::.||        ||      ...:...||.|..|.|||...|| .:::||..::|
Human   368 TVYEYLFSQRRKRRAPLATRQGKR------PSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEA 426

  Fly   533 YFCSGDCKV---GYLEQYPHTHLAALTTSATP------CCSPTKMSSLSLLYFDDNHNLVLSVIP 588
            :.|.|.|:.   .:||...|..:..|..|..|      ||.||::|.:|:|:.|..:|:|.....
Human   427 FHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYE 491

  Fly   589 NMSVEGCSC 597
            :|.||.|.|
Human   492 DMVVESCGC 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myoNP_726604.1 TGF_beta_GDF8_like 506..597 CDD:381629 35/100 (35%)
GDF5NP_000548.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..169
PTZ00449 <90..>168 CDD:185628
TGFb_propeptide 145..>296 CDD:480997 33/163 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..265 1/18 (6%)
TGF_beta_GDF5 399..501 CDD:381669 36/102 (35%)
Blue background indicates that the domain is not in the aligned region.

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