DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment myo and Tgfb2

DIOPT Version :9

Sequence 1:	NP_726604.1	Gene:	myo / 43811	FlyBaseID:	FBgn0026199	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_112393.2	Gene:	Tgfb2 / 81809	RGDID:	70491	Length:	442	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	109/493 - (22%)
Similarity:	183/493 - (37%)	Gaps:	141/493 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 SVSLYRNTLINIESMLQRQLREKAKVDSIESIKMHILMRLNLKKLP-NITKPISVPQNIID--NF 240
            ::||...:.::::..::::         ||:|:..||.:|.|...| :..:|..||..:|.  |.
  Rat    18 ALSLSTCSTLDMDQFMRKR---------IEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNS 73

  Fly   241 YRDY---NASSKTTVWNRMESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDL 302
            .||.   .||.:.....| |..||.:      |...:                       :.||:
  Rat    74 TRDLLQEKASRRAAACER-ERSDEEY------YAKEV-----------------------YKIDM 108

  Fly   303 NKNQAKKSDIP-INTNDEEYESILSHISSIY------IFPEEIQPHVRHNRKVDVFRFQI---DS 357
            ..:...::..| :.|:.....|..|..|.:.      |.|...:|:.|      :.||.:   :.
  Rat   109 PSHFPSETVCPVVTTSSGSVGSFCSRQSQVLCGYLDAIPPTFYRPYFR------IVRFDVSTMEK 167

  Fly   358 SYSDLSYATLHLY-LRGWDWISAHQPGLLEEIKKQPRKDIVVTIHRAI--RVANTTSFNPKVKMF 419
            :.|:|..|...:: |:......|.|...|.:|.|.  ||:.....|.|  :|..|.:
  Rat   168 NASNLVKAEFRVFRLQNPKARVAEQRIELYQILKS--KDLTSPTQRYIDSKVVKTRA-------- 222

  Fly   420 EFRHSIPSGLGQWVAVDLKSLL--------GNLG--------------------SNMTQEIL--- 453
                     .|:|::.|:...:        .|||                    .|.:||:.
  Rat   223 ---------EGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIPNKSQELEARF 278

  Fly   454 --IKGAETWMKSLVVTTDNTSK--NPLTVHIEI---------GSQKKHRRKRSVYMD---CTEND 502
              |.|..|:......|..:|.|  :..|.|:.:         ..|...||||:  :|   |..|.
  Rat   279 AGIDGTSTYASGDQKTIKSTRKKSSGKTPHLLLMLLPSYRLESQQSSRRRKRA--LDAAYCFRNV 341

  Fly   503 HDMRCCRYPLKVNF-TSFGWHFVVAPTSFDAYFCSGDCKVGYLEQYPHTHLAAL------TTSAT 560
            .| .||..||.::| ...||.::..|..::|.||:|.|...:.....||.:.:|      ..||:
  Rat   342 QD-NCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASAS 405

  Fly   561 PCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSCS 598
            |||....:..|::||:..| ...:..:.||.|:.|.||
  Rat   406 PCCVSQDLEPLTILYYIGN-TPKIEQLSNMIVKSCKCS 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta	506..597	CDD:278448	29/97 (30%)
Tgfb2	NP_112393.2	TGFb_propeptide	21..256	CDD:395559	57/298 (19%)
Tgfb2	NP_112393.2	TGF_beta_TGFB2	345..441	CDD:381655	29/96 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010