Protein Alignment myo and LEFTY2

DIOPT Version :10

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_003231.2
• Gene: LEFTY2 / 7044
• HGNCID: 3122
• Length: 366
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 80/385 - (20%)
• Similarity: 133/385 - (34%)
• Gaps: 118/385 - (30%)

  Fly   287 MQGDDANTVNEFLIDLNKNQAKKSDIPI-NTNDEEYESILSHISSIYIFPEEIQPHVRHNRKVDV 350
            :.|..|....|.|:.....|.:.|::|: :..|.|...|.:|:.:.|:    :.....|..:...
Human    15 LAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYV----VLLRRSHGDRSRG 75

  Fly   351 FRFQIDSSYSDL------SYATLHLYLRGWDWISAHQPGLLEEIKKQPRKDIVVTIHRAIRVANT 409
            .||  ..|:.::      |.|:.||.:.|.            |.:..|..::|..:.|..:
Human    76 KRF--SQSFREVAGRFLASEASTHLLVFGM------------EQRLPPNSELVQAVLRLFQ---- 122

  Fly   410 TSFNPKVKMFEFRHSIPSGLGQWVAVDLKSL-LGNLGSNMTQEI---LIKGAETWMKSLVVTTD- 469
               .|..|....||...|.......|.::.| :.:.|||.|..|   |:...|:..|:..||..
Human   123 ---EPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAV 184

  Fly   470 ------NTSKNPLTVHIEIGSQKKH----------------------------------RRKRSV 494
                  :..:.||.:.:.:  |::|                                  .|....
Human   185 NFWQQLSRPRQPLLLQVSV--QREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGA 247

  Fly   495 YMDC------TENDHDMRCCRYPLKVNFTSFGW--HFVVAPTSFDAYFCSGDCKVGYLEQYPHTH 551
            ..||      ||.   .||||..:.::.....|  ::|:.|..|.||.|.|.|      |.|...
Human   248 QGDCDPEAPMTEG---TRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTC------QQPPEA 303

  Fly   552 LAALTTSATP-CCSPTKMSSLSLLYFDDNHNLVLSV------------IPNMSVEGCSCS 598
            ||.......| .|..::.:||.         :::|:            :|||.|:.|||:
Human   304 LAFNWPFLGPRQCIASETASLP---------MIVSIKEGGRTRPQVVSLPNMRVQKCSCA 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	27/105 (26%)
LEFTY2	NP_003231.2	TGFb_propeptide	<106..203	CDD:480997	22/103 (21%)
		TGF_beta_LEFTY1_2	262..353	CDD:381636	27/105 (26%)