DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment myo and Tgfb1

DIOPT Version :9

Sequence 1:	NP_726604.1	Gene:	myo / 43811	FlyBaseID:	FBgn0026199	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_067589.1	Gene:	Tgfb1 / 59086	RGDID:	69051	Length:	390	Species:	Rattus norvegicus

Alignment Length:	447	Identity:	87/447 - (19%)
Similarity:	146/447 - (32%)	Gaps:	143/447 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 EKAKVDSIESIKMHILMRLNLKKLPN--ITKPISVPQNIID--NFYRDYNASSKTTVWNRMESID 260
            |..|...||:|:..||.:|.|...|:  ...|..:|:.::.  |..||..|.         ||.|
  Rat    39 ELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAG---------ESAD 94

  Fly   261 ESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTNDEEYESIL 325
            .......|.|                     |..|...|:             ::.|:..|:...
  Rat    95 PEPEPEADYY---------------------AKEVTRVLM-------------VDRNNAIYDKTK 125

  Fly   326 SHISSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYLRGWDWISAHQPGLLE--EI 388
            ....|||:|                      .:.||:..|             ..:|.||.  |:
  Rat   126 DITHSIYMF----------------------FNTSDIREA-------------VPEPPLLSRAEL 155

  Fly   389 KKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLLG---NLGSNMTQ 450
            :.|..|.   |:.:.:.:....| |...:....|...|:...:|::.|:..::.   |.|.
  Rat   156 RLQRFKS---TVEQHVELYQKYS-NNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGD---- 212

  Fly   451 EILIKGAETWMKSLVVTTDNTSKNPLTVHIEIG------------------------------SQ 485
                 |.:.:..|...:.|:...   .:|:||.                              :|
  Rat   213 -----GIQGFRFSAHCSCDSKDN---VLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQ 269

  Fly   486 KKH--RRKRSVYMDCTENDHDMRCCRYPLKVNF-TSFGWHFVVAPTSFDAYFCSGDCKVGYLEQY 547
            ..|  |.:|::..:...:..:..||...|.::| ...||.::..|..:.|.||.|.|...:....
  Rat   270 HLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDT 334

  Fly   548 PHTHLAAL------TTSATPCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSCS 598
            .::.:.||      ..||:|||.|..:..|.::|:......| ..:.||.|..|.||
  Rat   335 QYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKCS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta	506..597	CDD:278448	27/97 (28%)
Tgfb1	NP_067589.1	TGFb_propeptide	30..261	CDD:395559	54/315 (17%)
		Straightjacket domain. /evidence=ECO:0000250\|UniProtKB:P07200	30..74		11/34 (32%)
		Arm domain. /evidence=ECO:0000250\|UniProtKB:P07200	75..271		43/289 (15%)
		Bowtie tail. /evidence=ECO:0000250\|UniProtKB:P01137	226..252		4/28 (14%)
		Cell attachment site. /evidence=ECO:0000255	244..246		0/1 (0%)
		TGF_beta_TGFB1	292..390	CDD:381654	27/98 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010