DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myo and gdf6a

DIOPT Version :9

Sequence 1:NP_726604.1 Gene:myo / 43811 FlyBaseID:FBgn0026199 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_001153466.1 Gene:gdf6a / 566470 ZFINID:ZDB-GENE-980526-373 Length:404 Species:Danio rerio


Alignment Length:466 Identity:110/466 - (23%)
Similarity:164/466 - (35%) Gaps:157/466 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   197 QLREKAKVDSIESIKMHILMRLNLKKLPNITK------PISVPQNIIDNFYRDYNASSKTTVWNR 255
            |.|.|....:.:..:.|..::..|...|..::      |: ||.:.:.:.||.|:|:.|      
Zfish    30 QKRSKGARSAFDGQRSHKFLKEILASSPGASRRDDFKDPV-VPHDYMISIYRTYSAAEK------ 87

  Fly   256 MESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTNDEE 320
                    |.:|        ..||..|.|       |||:..| :|..|:....|.:...|    
Zfish    88 --------LGLN--------ASFFRSSKS-------ANTITSF-VDKGKDDLTLSPLRRQT---- 124

  Fly   321 YESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSD---LSYATLHLYLRGWDWISAHQP 382
                       |:|              ||      |:.||   |..|.|.::.:        .|
Zfish   125 -----------YLF--------------DV------STLSDKEELVGAELRIFRK--------SP 150

  Fly   383 GLLEEIKKQPRKDIVVTIH------------RAIRVANTTSFNPKV----KMFEFRH-------- 423
            |     ..||....|..:|            |:|.:.::.....:|    .:|:.||        
Zfish   151 G-----DVQPSPSGVYNLHLLSCRSERPLASRSIDLQDSRKAEWEVLDVWGIFKHRHQENQLCLQ 210

  Fly   424 -SIPSGLGQWVAVDLKSLLGNLGSNMTQEILIKGAETWMKSLVVTTDNTSKNPLTVHI------- 480
             .:..|... ..:|||.|..:..|...||..|         |||.|.:..:..|...:       
Zfish   211 LKVTYGKSD-TEIDLKQLGFHRHSRTQQERAI---------LVVYTRSKKRENLFNEMKEKIKSR 265

  Fly   481 ------EIGSQKKHRRKRSVYMDCTENDH--------DMRCCRYPLKVNFTSFGW-HFVVAPTSF 530
                  |...|.|.||:|...::   |.|        ..||.:..|.|||...|| .:::||..:
Zfish   266 GDDDEEESALQFKARRRRRTALN---NRHGKRHGKKSKSRCSKKALHVNFKELGWDDWIIAPLDY 327

  Fly   531 DAYFCSGDCKV---GYLEQYPHTHLAALTTSATP------CCSPTKMSSLSLLYFDDNHNLVLSV 586
            :||.|.|.|..   .:||...|..:..|..|..|      ||.|||:|.:|:||.|..:|:|...
Zfish   328 EAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPNSTPPSCCVPTKLSPISILYIDSGNNVVYKQ 392

  Fly   587 IPNMSVEGCSC 597
            ..:|.||.|.|
Zfish   393 YEDMVVEQCGC 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myoNP_726604.1 TGF_beta 506..597 CDD:278448 37/100 (37%)
gdf6aNP_001153466.1 TGFb_propeptide 57..245 CDD:279078 56/276 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..304 9/43 (21%)
TGFB 308..404 CDD:214556 36/96 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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