Protein Alignment myo and GDF6

DIOPT Version :9

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_001001557.1
• Gene: GDF6 / 392255
• HGNCID: 4221
• Length: 455
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 100/437 - (22%)
• Similarity: 152/437 - (34%)
• Gaps: 140/437 - (32%)

  Fly   229 PISVPQNIIDNFYRDYNASSKTTVWNRMESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDAN 293
            |..||...:.:.||.|:.:.|              |.||        ..||..|.|       ||
Human    90 PRVVPHEYMLSIYRTYSIAEK--------------LGIN--------ASFFQSSKS-------AN 125

  Fly   294 TVNEF----LIDLNKNQAKKSDIPINTNDEEYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQ 354
            |:..|    |.||:....::         ::|...:|.:|.    .||:.     ..::.:|| |
Human   126 TITSFVDRGLDDLSHTPLRR---------QKYLFDVSMLSD----KEELV-----GAELRLFR-Q 171

  Fly   355 IDSSYSDLSYATLHLYL---------------------RGWDWISAHQPGLLEEIKKQPRKDIVV 398
            ..|:........||:.|                     .||:.....| ||    :.||.|.:.:
Human   172 APSAPWGPPAGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQ-GL----RHQPWKQLCL 231

  Fly   399 TIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLLGNLGSNMTQEILIKGAETWMKS 463
            .:..|....:......:.:          |..|....||:||.........||..:
Human   232 ELRAAWGELDAGEAEARAR----------GPQQPPPPDLRSLGFGRRVRPPQERAL--------- 277

  Fly   464 LVVTTDNTSKNPLT-VHIEIGSQKK----------------------------HRRKRSVYMDCT 499
            |||.|.:..||... :..::||.:.                            .||:|:.:....
Human   278 LVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRH 342

  Fly   500 ENDHD----MRCCRYPLKVNFTSFGW-HFVVAPTSFDAYFCSGDCKV---GYLEQYPHTHLAALT 556
            ...|.    :||.:.||.|||...|| .:::||..::||.|.|.|..   .:||...|..:..|.
Human   343 GKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLM 407

  Fly   557 TSATP------CCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSC 597
            .|..|      ||.|||::.:|:||.|..:|:|.....:|.||.|.|
Human   408 NSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta	506..597	CDD:278448	37/100 (37%)
GDF6	NP_001001557.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..93		1/2 (50%)
		TGFb_propeptide	79..281	CDD:395559	52/262 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..267		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..351		4/50 (8%)
		TGF_beta_GDF5_6_7	354..455	CDD:381644	37/101 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910