DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myo and INHBA

DIOPT Version :9

Sequence 1:NP_726604.1 Gene:myo / 43811 FlyBaseID:FBgn0026199 Length:598 Species:Drosophila melanogaster
Sequence 2:XP_016867663.1 Gene:INHBA / 3624 HGNCID:6066 Length:548 Species:Homo sapiens


Alignment Length:454 Identity:95/454 - (20%)
Similarity:166/454 - (36%) Gaps:140/454 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 DSIESIKMHILMRLNLKKLPNITKPISVPQNIIDNFYRDYNASSKTTVWNRMESIDESHLSINDT 269
            :.:|::|.|||..|:|||.|::|:|  ||:..:.|..|..:.....         :..::.|.|.
Human   175 EMVEAVKKHILNMLHLKKRPDVTQP--VPKAALLNAIRKLHVGKVG---------ENGYVEIEDD 228

  Fly   270 YGDHIMTDFFDESSSSQMQGDDANTVNEFL-IDLNKNQAKKSDIPINTNDEEYESILSHISSIYI 333
            .|.....:...|.:|..:...::.|..:.| .:::|   :.||:.:....|           :::
Human   229 IGRRAEMNELMEQTSEIITFAESGTARKTLHFEISK---EGSDLSVVERAE-----------VWL 279

  Fly   334 FPEEIQPHVRHNR-KVDVFRFQIDSSYSDLSYATLHLYLRGWDWISAHQPGLL------EEIKKQ 391
            |.:  .|.....| ||.:..||...                      |..|.|      ||:..:
Human   280 FLK--VPKANRTRTKVTIRLFQQQK----------------------HPQGSLDTGEEAEEVGLK 320

  Fly   392 PRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLLGNLGSNMTQEILIKG 456
            ..:..::...:.:....:|           .|..|      |:..::.||....|::...|..:.
Human   321 GERSELLLSEKVVDARKST-----------WHVFP------VSSSIQRLLDQGKSSLDVRIACEQ 368

  Fly   457 AETWMKSLVVTTDNTSKNPLTVHIEIGSQKK---------------------------------H 488
            .:....|||:......|.      |.|..||                                 |
Human   369 CQESGASLVLLGKKKKKE------EEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPH 427

  Fly   489 RRKRSVYMDCTENDHDMR-CCRYPLKVNFTSFGWH-FVVAPTSFDAYFCSGDCK----------- 540
            ||:|. .::|   |..:. ||:....|:|...||: :::||:.:.|.:|.|:|.           
Human   428 RRRRR-GLEC---DGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSL 488

  Fly   541 ------VGYLEQYPHTHLAALTTSATPCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSCS 598
                  :.:.....|:..|.|.:    ||.|||:..:|:||:||..|::...|.||.||.|.||
Human   489 SFHSTVINHYRMRGHSPFANLKS----CCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myoNP_726604.1 TGF_beta 506..597 CDD:278448 32/109 (29%)
INHBAXP_016867663.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11848
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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