Protein Alignment myo and BMP10

DIOPT Version :10

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_055297.1
• Gene: BMP10 / 27302
• HGNCID: 20869
• Length: 424
• Species: Homo sapiens
• Alignment Length: 454
• Identity: 94/454 - (20%)
• Similarity: 146/454 - (32%)
• Gaps: 154/454 - (33%)

  Fly   248 SKTTVWNRMESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTV-----NEFLIDLNKNQA 307
            |.:.:.|..:|..|..:|:   :||..          |:..|.|.||:     :|||..||
Human    20 SGSPIMNLEQSPLEEDMSL---FGDVF----------SEQDGVDFNTLLQSMKDEFLKTLN---- 67

  Fly   308 KKSDIPINTNDEEYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYLR 372
             .||||  |.|           |..:.|.|....:.:....|  |..:.|:....|:....|:
Human    68 -LSDIP--TQD-----------SAKVDPPEYMLELYNKFATD--RTSMPSANIIRSFKNEDLF-- 114

  Fly   373 GWDWISAHQPGLLEEIKKQPRK-DIVVTIHRAIRVANTTSF-------------NPKVKMFEFRH 423
                   .||.....::|.|.. ::.:..|..:.:|....:             :.|:.:||...
Human   115 -------SQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLE 172

  Fly   424 SIPSGLGQWVAVDLKSLLGNL-GSNMTQEI--LIKGAETWMKSLVVTTDNTSKNPLTVHIE---- 481
            |.....|:...:.|.|  |.: |:|...|.  :......|.||      .:|.:.|.||||
Human   173 SKGDNEGERNMLVLVS--GEIYGTNSEWETFDVTDAIRRWQKS------GSSTHQLEVHIESKHD 229

  Fly   482 -------------IGSQKKHRRKRSVYMDCTENDHDMR--------------------------- 506
                         ..:|.||.....|:.|...:|.:.:
Human   230 EAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGP 294

  Fly   507 ----------------------------CCRYPLKVNFTSFGW-HFVVAPTSFDAYFCSGDCKVG 542
                                        |.|.||.::|...|| .:::||..::||.|.|.|...
Human   295 GEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYP 359

  Fly   543 YLEQYPHT---------HLAALTTSATPCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSC 597
            ..|....|         ||.....::..||.|||:..:|:||.|............|:|..|.|
Human   360 LAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	30/155 (19%)
BMP10	NP_055297.1	TGFb_propeptide	55..256	CDD:480997	48/237 (20%)
		TGF_beta_BMP10	321..424	CDD:381671	31/103 (30%)