Protein Alignment myo and GDF9

DIOPT Version :10

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_005251.1
• Gene: GDF9 / 2661
• HGNCID: 4224
• Length: 454
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 84/464 - (18%)
• Similarity: 155/464 - (33%)
• Gaps: 176/464 - (37%)

  Fly   253 WNRMESIDESHLSINDTYGDHIMTDFF-----DESSSSQMQGDDANTVNEFLIDLNKNQAKKSDI 312
            |:.::.|||     .|..|  ::...|     ....|.::|.|  :....::..|.|..|.|..|
Human    47 WSLLQHIDE-----RDRAG--LLPALFKVLSVGRGGSPRLQPD--SRALHYMKKLYKTYATKEGI 102

  Fly   313 PINTNDEEYESILSHI-SSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYLRGWDW 376
            |        :|..||: :::.:|    .|..||.:...                         |.
Human   103 P--------KSNRSHLYNTVRLF----TPCTRHKQAPG-------------------------DQ 130

  Fly   377 ISAHQPGLLEEIKKQPRKDIVVTIHRAIR------VANTTSFNPKVK------------------ 417
            ::    |:|..::.....|.:.|:...::      :.|:.||:..||
Human   131 VT----GILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLG 191

  Fly   418 ----------MFEF--RHSIPSGLGQWVAVDLKSLLGNLGSNMTQEILIKGAETWMK-------- 462
                      .|||  :|       :|:.:|:.|||..|.::..:.|.:....|.||
Human   192 RAPYSFTFNSQFEFGKKH-------KWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSA 249

  Fly   463 ------------SLVVTTDNTS----------------------KNPLTVH------IEIGSQKK 487
                        ||::..::||                      :..|:.:      .|.|....
Human   250 QNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSH 314

  Fly   488 HRRKRSVYMDCTENDHDM-------------------RCCRYPLKVNFTSFGW-HFVVAPTSFDA 532
            ||.:|......:|....:                   .|..:..:::|:...| :::|||..::.
Human   315 HRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNP 379

  Fly   533 YFCSGDC--KVGYLEQYP-HTHLAAL------TTSATPCCSPTKMSSLSLLYFDDNHNLVLSVIP 588
            .:|.|||  .||:....| ||.:..:      ::...|.|.|.|.|.||:|..:.:.::......
Human   380 RYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYE 444

  Fly   589 NMSVEGCSC 597
            :|....|:|
Human   445 DMIATKCTC 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	25/100 (25%)
GDF9	NP_005251.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..330		6/26 (23%)
		TGF_beta_GDF9	349..454	CDD:381673	26/105 (25%)