Protein Alignment myo and MSTN

DIOPT Version :9

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_005250.1
• Gene: MSTN / 2660
• HGNCID: 4223
• Length: 375
• Species: Homo sapiens
• Alignment Length: 420
• Identity: 118/420 - (28%)
• Similarity: 183/420 - (43%)
• Gaps: 109/420 - (25%)

  Fly   199 REKAKVDSIESIKMHILMRLNLKKLPNITK-------PISVP-QNIIDNFYRDYNASSKTTVWNR 255
            |:..|...||:||:.||.:|.|:..|||:|       |.:.| :.:||.:
Human    45 RQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQY--------------- 94

  Fly   256 MESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTNDEE 320
                |...                |:||...::.||.:...|.:|.:    ..:||
Human    95 ----DVQR----------------DDSSDGSLEDDDYHATTETIITM----PTESD--------- 126

  Fly   321 YESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYLRGWDWISAHQPGLL 385
                       ::...:.:|      |...|:|.....|:.:..|.|.:|||..:..:.....:|
Human   127 -----------FLMQVDGKP------KCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQIL 174

  Fly   386 EEIKKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLL--------G 442
            ..||  |.||  .|.:..|| :.....||             |.|.|.::|:|::|        .
Human   175 RLIK--PMKD--GTRYTGIR-SLKLDMNP-------------GTGIWQSIDVKTVLQNWLKQPES 221

  Fly   443 NLGSNMTQEILIKGAETWMKSLVVTTDNTSKNPLTVHIEIG-SQKKHRRKRSVYMDCTENDHDMR 506
            |||      |.||..:.....|.||.....::.|...:|:. :....|.:|...:||.|:..:.|
Human   222 NLG------IEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESR 280

  Fly   507 CCRYPLKVNFTSFGWHFVVAPTSFDAYFCSGDCKVGYLEQYPHTHL---AALTTSATPCCSPTKM 568
            ||||||.|:|.:|||.:::||..:.|.:|||:|:..:|::||||||   |....||.|||:||||
Human   281 CCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKM 345

  Fly   569 SSLSLLYFDDNHNLVLSVIPNMSVEGCSCS 598
            |.:::|||:....::...||.|.|:.|.||
Human   346 SPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta	506..597	CDD:278448	45/93 (48%)
MSTN	NP_005250.1	TGFb_propeptide	39..249	CDD:279078	64/292 (22%)
		TGFB	281..375	CDD:214556	44/93 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6128
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3850
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4266
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001977
OrthoInspector	1	1.000	-	-		otm41502
orthoMCL	1	0.900	-	-		OOG6_105895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2472
SonicParanoid	1	1.000	-	-		X1292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890