Protein Alignment myo and GDF2

DIOPT Version :10

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_057288.1
• Gene: GDF2 / 2658
• HGNCID: 4217
• Length: 429
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 98/423 - (23%)
• Similarity: 165/423 - (39%)
• Gaps: 85/423 - (20%)

  Fly   207 IESIKMHILMRLNLKKLPNITKP-ISVPQNIIDNFYRDYNASSKTTVWNRMESID-ESHLSINDT 269
            :|::|:..|..|||..:|:..|. :..||.:||.:.|..:..|.|...|.:.|.. |..:||..|
Human    59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITAT 123

  Fly   270 ----YGDHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKN-QAKKSDIPINTNDEEYESILSHI- 328
                :..||:.                     |.|.:.:: |..::::.:      |.|..:|:
Human   124 EDFPFQKHILL---------------------FNISIPRHEQITRAELRL------YVSCQNHVD 161

  Fly   329 ------SSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYLRGWDWISAHQPGLLEE 387
                  .|:.|: :.:......:...:...|.:.....|..:.||.:......|:.:      :.
Human   162 PSHDLKGSVVIY-DVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRS------DS 219

  Fly   388 IKKQPRKDIVVTIHRA------IRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLLGNLGS 446
            .|.:.:.::.|..||.      |.|...:...|...:|...||  ||..: ..::|:.::.:...
Human   220 TKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHS--SGTKE-TRLELREMISHEQE 281

  Fly   447 NMTQEILIKGA-ETWMKSLVVTTDNTSKNPLTVHIEIGSQKKHRRKRSVYMDCTENDHDMRCCRY 510
            ::.:::...|: |....|....||.        |:..||... |||||    .....|   |.:.
Human   282 SVLKKLSKDGSTEAGESSHEEDTDG--------HVAAGSTLA-RRKRS----AGAGSH---CQKT 330

  Fly   511 PLKVNFTSFGW-HFVVAPTSFDAYFCSGDCKVGYLEQYPHT---------HLAALTTSATPCCSP 565
            .|:|||...|| .:::||..::||.|.|.|.....:....|         ||...|.....||.|
Human   331 SLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVP 395

  Fly   566 TKMSSLSLLYFDDNHNLVLSV-IPNMSVEGCSC 597
            ||:|.:|:||.||.....|.. ...|||..|.|
Human   396 TKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	34/101 (34%)
GDF2	NP_057288.1	TGFb_propeptide	70..217	CDD:480997	33/174 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..308		5/32 (16%)
		TGF_beta_BMP9	325..429	CDD:381670	36/107 (34%)
		Interaction with ENG. /evidence=ECO:0000269|PubMed:28564608	402..416		6/13 (46%)