DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment myo and Bmp6

DIOPT Version :9

Sequence 1:	NP_726604.1	Gene:	myo / 43811	FlyBaseID:	FBgn0026199	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_038951315.1	Gene:	Bmp6 / 25644	RGDID:	2214	Length:	535	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	100/531 - (18%)
Similarity:	178/531 - (33%)	Gaps:	187/531 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 LQRQLREKAKVDSIESIKMHILMRLNLKKLPNITKPISVPQNII--------------------- 237
            |.|:|:...|    ..::..||..|.|...|.....:..||:.:
  Rat    64 LYRRLKTHEK----REMQKEILSVLGLPHRPRPLHGLQQPQSPVLPQQQQSQQTAREEPPPGRLK 124

  Fly   238 --DNFYRD-YNASSKTTVWNRMESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFL 299
              ..|..| ||:.||          |:....:::  |:.:..:....:||||::.......:
  Rat   125 SAPLFMLDLYNSLSK----------DDEEDGVSE--GEGLEPESHGRASSSQLKQPSPGAAH--- 174

  Fly   300 IDLNKNQAKK-----SDIPINTNDE-----EYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQ 354
             .||:.....     |..|:.:..:     :.:.::|.::.:. :.:|..|..||:::   |:|.
  Rat   175 -SLNRKSLLAPGPGGSASPLTSAQDSAFLNDADMVMSFVNLVE-YDKEFSPRQRHHKE---FKFN 234

  Fly   355 IDS-------------SYSDLSYATL--HLYLRGWDWISAHQPGLLEEIKKQPRKDIVVTIHRAI 404
            :..             .|.|....:.  ..:|     ||.:|  :|:|  .|.|...:..:...:
  Rat   235 LSQIPEGEAVTAAEFRVYKDCVVGSFKNQTFL-----ISIYQ--VLQE--HQHRDSDLFLLDTRV 290

  Fly   405 RVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLLGNLGSNMTQEILIKGAETWMKSLVVTTD 469
            ..|:...:      .||..:..|.|  ||.....    |:|..::               |||.|
  Rat   291 VWASEEGW------LEFDITATSNL--WVVTPQH----NMGLQLS---------------VVTRD 328

  Fly   470 NTSKNPLT------------------------VHIEIGSQKKHRRKR---------------SVY 495
            ....||..                        ||:........||::               |..
  Rat   329 GLHINPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVSRGSSA 393

  Fly   496 MDCTENDHDMRCCRYPLKVNFTSFGWH-FVVAPTSFDAYFCSGDCKV---GYLEQYPHTHLAALT 556
            .|...::....|.::.|.|:|...||. :::||..:.|.:|.|:|..   .::....|..:..|.
  Rat   394 SDYNSSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLV 458

  Fly   557 TSAT-----------------------------------PCCSPTKMSSLSLLYFDDNHNLVLSV 586
            ::.|                                   |||:|||::::|:||||||.|::|..
  Rat   459 SALTWLVGPGLDPVSFLTVSSHASLLEQVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKK 523

  Fly   587 IPNMSVEGCSC 597
            ..||.|..|.|
  Rat   524 YRNMVVRACGC 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta	506..597	CDD:278448	34/129 (26%)
Bmp6	XP_038951315.1	TGFb_propeptide	58..355	CDD:395559	59/350 (17%)
Bmp6	XP_038951315.1	TGF_beta_BMP6	404..535	CDD:381666	35/131 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910