DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment myo and Gdf6

DIOPT Version :9

Sequence 1:	NP_726604.1	Gene:	myo / 43811	FlyBaseID:	FBgn0026199	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001013056.1	Gene:	Gdf6 / 252834	RGDID:	620104	Length:	452	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	114/513 - (22%)
Similarity:	175/513 - (34%)	Gaps:	168/513 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 DLSRVQSVSLYRNTLINIESMLQRQLREKAKV-----DSIE--SIKMH------ILMRL---NLK 221
            ||...|..|:..::...::|....:.|:..|:     :|.|  :.|.|      :..||   :|.
  Rat    19 DLPGFQQASISSSSSTELDSTKDVENRKGGKMQRTPQESAEGRTPKEHRPRPNELRRRLPGQSLG 83

  Fly   222 KLPNITKPISVPQNIIDNFYRDYNASSKTTVWNRMESIDESHLSINDTYGDHIMTDFFDESSSSQ 286
            :.|....|..||...:.:.||.|:.:.|              |.||        ..||..|.|
  Rat    84 QEPPGRGPRVVPHEYMLSIYRTYSIAEK--------------LGIN--------ASFFQSSKS-- 124

  Fly   287 MQGDDANTVNEF----LIDLNKNQAKKS----DIPINTNDEEYESILSHISSIYIF----PEEIQ 339
                 |||:..|    |.||:....::.    |:...::.||...     :.:.::    |....
  Rat   125 -----ANTITSFVDRGLDDLSHTPLRRQKYLFDVSTLSDKEELVG-----AELRLYRQAPPTPWG 179

  Fly   340 PHVRHNRKVDVFRFQIDSSYSDLSYATLHLYL---------------------RGWDWISAHQPG 383
            |..|                      .|||.|                     .||:.....|
  Rat   180 PQTR----------------------PLHLQLFPCLSPLLLDSRTLDPQGPTEAGWEVFDVWQ-- 220

  Fly   384 LLEEIKKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLLGNLGSNM 448
               .::.||.|.:.:.:.......:......:          |.|..|...:||:||........
  Rat   221 ---VLRPQPWKQLCLELRAVWGELDARDSGAR----------PRGPQQSPPLDLRSLGFGRRVRP 272

  Fly   449 TQEILIKGAETWMKSLVVTTDNTSKNPLT-VHIEIGSQKK------------------------H 488
            .||..:         |||.|.:..||..| :|.::||.:.                        .
  Rat   273 PQERAL---------LVVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGAPDAGSWLPSPGR 328

  Fly   489 RRKRSVYMDCTENDHD----MRCCRYPLKVNFTSFGW-HFVVAPTSFDAYFCSGDCKV---GYLE 545
            ||:|:.........|.    :||.|.||.|||...|| .:::||..::||.|.|.|..   .:||
  Rat   329 RRRRTALSSRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLE 393

  Fly   546 QYPHTHLAALTTSATP------CCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSC 597
            ...|..:..|..|..|      ||.|||::.:|:||.|..:|:|.....:|.||.|.|
  Rat   394 PTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta	506..597	CDD:278448	38/100 (38%)
Gdf6	NP_001013056.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..93		12/63 (19%)
		TGFb_propeptide	66..282	CDD:279078	53/295 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..267		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..348		4/46 (9%)
		TGF_beta	350..451	CDD:278448	38/100 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910