Protein Alignment myo and Gdf6

DIOPT Version :10

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_038554.1
• Gene: Gdf6 / 242316
• MGIID: 95689
• Length: 454
• Species: Mus musculus
• Alignment Length: 521
• Identity: 117/521 - (22%)
• Similarity: 178/521 - (34%)
• Gaps: 163/521 - (31%)

  Fly   150 FQMKVQSKPGKKSTPLAKVSEHGDLSRVQSVSLYRNTLINIESMLQRQLREKAKVDSIESIKMHI 214
            ||....|.....||.|....:.|:..               |..:||..:|.|:.   .:...|.
Mouse    23 FQQASISSSSSSSTELDSTKDVGNRK---------------EGKMQRTPQESAEG---RTPPEHG 69

  Fly   215 LMRLNLKKLP----NITKPIS-----VPQNIIDNFYRDYNASSKTTVWNRMESIDESHLSINDTY 270
            |.:.:|::.|    ...:|..     ||...:.:.|:.|:.:.|              |.||
Mouse    70 LRQKDLRRRPPGQHQGQEPPGRGLRVVPHEYMLSIYKTYSIAEK--------------LGIN--- 117

  Fly   271 GDHIMTDFFDESSSSQMQGDDANTVNEF----LIDLNKNQAKKSDIPINTNDEEYESILSHISSI 331
                 ..||..|.|       |||:..|    |.||:....::            :..|..:|::
Mouse   118 -----ASFFQSSKS-------ANTITSFVDRGLDDLSHTPLRR------------QKYLFDVSTL 158

  Fly   332 YIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYL---------------------RGWD 375
            ....|.:...:|..|       |...:...|....|||.|                     .||:
Mouse   159 SDKEELVGAELRLYR-------QAPPTPWGLPARPLHLQLFPCLSPLLLDARTLDPQGPTQAGWE 216

  Fly   376 WISAHQPGLLEEIKKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSL 440
            .....| ||    :.||.|.:.:.:..|....:......:.:          |..|...:||:||
Mouse   217 VFDVWQ-GL----RPQPWKQLCLELRAAWGELDAGDTGARAR----------GPQQPPPLDLRSL 266

  Fly   441 LGNLGSNMTQEILIKGAETWMKSLVVTTDNTSKNPLT-VHIEIGSQKK----------------- 487
            .........||..:         |||.|.:..||..| :|.::||.:.
Mouse   267 GFGRRVRPPQERAL---------LVVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGSPDAG 322

  Fly   488 -------HRRKRSVYMDCTENDHD----MRCCRYPLKVNFTSFGW-HFVVAPTSFDAYFCSGDCK 540
                   .||:|:.:.......|.    :||.|.||.|||...|| .:::||..::||.|.|.|.
Mouse   323 SWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCD 387

  Fly   541 V---GYLEQYPHTHLAALTTSATP------CCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCS 596
            .   .:||...|..:..|..|..|      ||.|||::.:|:||.|..:|:|.....:|.||.|.
Mouse   388 FPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCG 452

  Fly   597 C 597
            |
Mouse   453 C 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	38/100 (38%)
Gdf6	NP_038554.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..93		15/82 (18%)
		TGFb_propeptide	75..284	CDD:480997	52/280 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..268		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..350		4/46 (9%)
		TGF_beta_GDF5_6_7	353..454	CDD:381644	38/101 (38%)